VEGFR2/KDR: VEGFR2/KDR Protein | VEGFR2/KDR Antibody

VEGFR2/KDR Gene family

VEGFR2/KDR Protein

VEGFR2/KDR protein function

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. {ECO:0000269|PubMed:10102632, ECO:0000269|PubMed:10368301, ECO:0000269|PubMed:10600473, ECO:0000269|PubMed:11387210, ECO:0000269|PubMed:12649282, ECO:0000269|PubMed:1417831, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15215251, ECO:0000269|PubMed:15962004, ECO:0000269|PubMed:16966330, ECO:0000269|PubMed:17303569, ECO:0000269|PubMed:18529047, ECO:0000269|PubMed:19668192, ECO:0000269|PubMed:19834490, ECO:0000269|PubMed:20080685, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20705758, ECO:0000269|PubMed:21893193, ECO:0000269|PubMed:7929439, ECO:0000269|PubMed:9160888, ECO:0000269|PubMed:9804796, ECO:0000269|PubMed:9837777}.

VEGFR2/KDR protein expression

Tissue specificity

Detected in cornea (at protein level). Widely expressed.

VEGFR2/KDR protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,356.00
  • Mass (Da)
    151.00

VEGFR2/KDR Antibody

There are 31 VEGFR2/KDR antibodies which are validated in multiple tissues with various applications, including FCM, ELISA, ELISA(Cap), IHC-P, ICC/IF. There are 18 VEGFR2/KDR antibody for FCM, 13 VEGFR2/KDR antibody for ELISA, 1 VEGFR2/KDR antibody for ELISA(Cap), 3 VEGFR2/KDR antibody for IHC-P, 2 VEGFR2/KDR antibody for ICC/IF. Among all these VEGFR2/KDR antibodies, there are 8 anti-VEGFR2/KDR mouse monoclonal antibodies , 14 anti-VEGFR2/KDR rabbit monoclonal antibodies , 9 anti-VEGFR2/KDR rabbit polyclonal antibodies . All the VEGFR2/KDR anbodies are produced in house and all are in stock. VEGFR2/KDR antibody customerized service is available.

VEGFR2/KDR Gene

KDR gene / cDNA is a protein-coding gene which located on 4q12. The KDR gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.238 organisms have orthologs with human gene KDR.