uPAR/PLAUR cDNA Clone: Expression and Clone Vector / Plasmid

uPAR/PLAUR cDNA / Gene Overview

PLAUR gene / cDNA is a protein-coding gene which located on 19q13. The PLAUR gene is conserved in chimpanzee, dog, cow, mouse, and rat.129 organisms have orthologs with human gene PLAUR.

uPAR/PLAUR cDNA / Gene Function

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

uPAR/PLAUR cDNA / Gene Sequence

LOCUS
LOCUS NM_002659 1570 bp mRNA linear PRI 15-JUL-2018
DEFINITION
Homo sapiens plasminogen activator, urokinase receptor (PLAUR), transcript variant 1, mRNA.
ACCESSION
NM_002659
VERSION
NM_002659.3

This sequence information is just for reference only.

uPAR/PLAUR Family & Reagents

uPAR/PLAUR Gene family reagents (CD molecules)

Approved Symbol Reagent list
IGF1R
CRTAM
IL12RB1
ERBB2
ICOS
ICAM3
CTLA4
TFRC
PTGFRN
FCRL1
Approved Symbol Reagent list
NCR2
LEPR
SPN
LY9
CD58
NRP1
PROCR
CD7
THY1
MELTF

uPAR/PLAUR Gene family reagents (LY6/PLAUR domain containing)

Approved Symbol Reagent list
CD177
GPIHBP1
LYPD3
Approved Symbol Reagent list
CD59
LY6D
   

uPAR/PLAUR cDNA / Gene Alias

  • CD87
  • UPAR
  • URKR
  • urokinase plasminogen activator surface receptor
  • urokinase-type plasminogen activator (uPA) receptor

uPAR/PLAUR cDNA / Gene Expression

Biased expression in bone marrow (RPKM 100.8), gall bladder (RPKM 18.1) and 5 other tissues

Recombinant uPAR/PLAUR protein citations

Title
Three Testis-Specific Paralogous Serine Proteases Play Different Roles in Murine Spermatogenesis and Are Involved in Germ Cell Survival During Meiosis 1
Year
2013
Author
Yoneda, R;Takahashi, T;Matsui, H;Takano, N;
Journal
Biology of Reproduction