TrkC Gene Sequence, Family, Fuction and Expression Information

TrkC cDNA / Gene Overview

NTRK3 gene / cDNA is a protein-coding gene which located on 15q25.3. The NTRK3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.223 organisms have orthologs with human gene NTRK3.

TrkC cDNA / Gene Function

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

TrkC cDNA / Gene Sequence

LOCUS
LOCUS NM_001007156 4141 bp mRNA linear PRI 29-JUL-2018
DEFINITION
Homo sapiens neurotrophic receptor tyrosine kinase 3 (NTRK3), transcript variant 3, mRNA.
ACCESSION
NM_001007156
VERSION
NM_001007156.2

This sequence information is just for reference only.

TrkC Family & Reagents

TrkC Gene family reagents (Receptor Tyrosine Kinases)

Approved Symbol Reagent list
FGFR2
AXL
DDR2
KDR
NTRK1
FGFR3
PDGFRA
MST1R
ROR2
NTRK2
Approved Symbol Reagent list
FLT3
PDGFRB
MERTK
MET
Tie1
CSF1R
RET
PTK7
FLT4
INSR

TrkC Gene family reagents (I-set domain containing)

Approved Symbol Reagent list
NRG1
CNTN3
IGFBP7
ROR2
FGFR1
VSIG2
FLT4
KIRREL3
KIRREL1
CLMP
Approved Symbol Reagent list
CHL1
ADAMTSL1
CDON
FGFR3
UNC5B
FGFR4
NECTIN3
OPCML
ROBO2
NCAM2

TrkC cDNA / Gene Alias

  • TRKC

TrkC cDNA / Gene Expression

Biased expression in brain (RPKM 2.8), fat (RPKM 1.2) and 13 other tissues