TNFR2/TNFRSF1B Gene Sequence, Family, Fuction and Expression Information

TNFR2/TNFRSF1B cDNA / Gene Overview

TNFRSF1B gene / cDNA is a protein-coding gene which located on 1p36.22. The TNFRSF1B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.167 organisms have orthologs with human gene TNFRSF1B.

TNFR2/TNFRSF1B cDNA / Gene Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

TNFR2/TNFRSF1B cDNA / Gene Sequence

LOCUS
LOCUS NM_001066 3682 bp mRNA linear PRI 12-AUG-2018
DEFINITION
Homo sapiens TNF receptor superfamily member 1B (TNFRSF1B), mRNA.
ACCESSION
NM_001066
VERSION
NM_001066.2

This sequence information is just for reference only.

TNFR2/TNFRSF1B Family & Reagents

TNFR2/TNFRSF1B Gene family reagents (CD molecules)

Approved Symbol Reagent list
PVR
CD209
SIGLEC6
FCRL2
KIR3DL3
KLRC1
FGFR3
SEMA4D
CDH5
CD180
Approved Symbol Reagent list
KIR2DL5A
GYPC
CD74
TREM1
KIR2DL4
CD207
LY9
LILRA5
SPN
IL10RB

TNFR2/TNFRSF1B Gene family reagents (Tumor necrosis factor receptor superfamily)

Approved Symbol Reagent list
TNFRSF9
TNFRSF19
FAS
TNFRSF10B
TNFRSF18
TNFRSF13B
TNFRSF6B
EDAR
LTBR
TNFRSF21
Approved Symbol Reagent list
TNFRSF8
TNFRSF10A
EDA2R
TNFRSF25
TNFRSF14
TNFRSF13C
TNFRSF10D
TNFRSF12A
CD27
TNFRSF11A

TNFR2/TNFRSF1B cDNA / Gene Alias

  • CD120b
  • p75
  • TNFBR
  • TNF-R75
  • TNFR80
  • TNF-R-II

TNFR2/TNFRSF1B cDNA / Gene Expression

Broad expression in appendix (RPKM 31.9), spleen (RPKM 25.2) and 23 other tissues

Recombinant TNFR2/TNFRSF1B protein citations

Title
EphB4/ TNFR2/ERK/MAPK signaling pathway comprises a signaling axis to mediate the positive effect of TNF-α on osteogenic differentiation
Year
2020
Author
Zhang, Y;Yang, C;Ge, S;Wang, L;Zhang, J;Yang, P;
Journal
BMC Mol Cell Biol
Title
The TNF/TNFR2 signaling pathway is a key regulatory factor in endothelial progenitor cell immunosuppressive effect
Year
2020
Author
Naserian, S;Abdelgawad, ME;Afshar Bakshloo, M;Ha, G;Arouche, N;Cohen, JL;Salomon, BL;Uzan, G;
Journal
Cell Commun. Signal