TIM-3 Gene Sequence, Family, Fuction and Expression Information

TIM-3 cDNA / Gene Overview

HAVCR2 gene / cDNA is a protein-coding gene which located on 5q33.3. The HAVCR2 gene is conserved in chimpanzee, dog, cow, mouse, and rat.128 organisms have orthologs with human gene HAVCR2.

TIM-3 cDNA / Gene Function

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

TIM-3 cDNA / Gene Sequence

LOCUS
LOCUS NM_032782 2448 bp mRNA linear PRI 29-JUL-2018
DEFINITION
Homo sapiens hepatitis A virus cellular receptor 2 (HAVCR2), mRNA.
ACCESSION
NM_032782
VERSION
NM_032782.4

This sequence information is just for reference only.

TIM-3 Family & Reagents

TIM-3 Gene family reagents (V-set domain containing)

Approved Symbol Reagent list
SLAMF7
SIGLEC6
CD276
NECTIN1
BTN3A2
SLAMF6
SIGLEC10
CD28
PILRA
CD300LF
Approved Symbol Reagent list
SCN2B
PTGFRN
CD226
NECTIN4
CEACAM1
F11R
CXADR
BTN3A3
CRTAM
CD79B

TIM-3 cDNA / Gene Alias

  • CD366
  • FLJ14428
  • T-cell immunoglobulin mucin family member 3
  • TIM3
  • Tim-3
  • TIMD3

TIM-3 cDNA / Gene Expression

Broad expression in lymph node (RPKM 12.1), spleen (RPKM 10.5) and 23 other tissues

Recombinant TIM-3 protein citations

Title
Soluble Tim3 detection by time-resolved fluorescence immunoassay and its application in membranous nephropathy
Year
2020
Author
Chen, M;Wang, L;Wang, Y;Zhou, X;Liu, X;Chen, H;Huang, B;Hu, Z;
Journal
J. Clin. Lab. Anal.
Title
Soluble Tim3 detection by time-resolved fluorescence immunoassay and its application in membranous nephropathy
Year
2020
Author
Chen, M;Wang, L;Wang, Y;Zhou, X;Liu, X;Chen, H;Huang, B;Hu, Z;
Journal
J. Clin. Lab. Anal.