TIM-1/KIM-1 Protein Overview: Sequence, Structure, Function and Protein Interaction

TIM-1/KIM-1 Protein Overview

Hepatitis A virus (HAV), a major cause of orally transmitted acute hepatitis, infects primate cells, but not dog or mouse cells, after binding to the HAV cellular receptor (HAVCR). Using RT-PCR with primers specific to the African green monkey Havcr to screen liver and kidney cDNA, Feigelstock et al. (1998) isolated a cDNA encoding human HAVCR1. Sequence analysis predicted that the 359-amino acid type I HAVCR1 glycoprotein, which is 79% identical to the monkey protein, contains a signal sequence; a 109-amino acid cys-rich N-terminal region with only 1 conserved N-glycosylation site; a 163-amino acid TSP-rich region with 3 N-glycosylation sites, 2 of which are conserved; and a 48-amino acid intracellular domain, 12 residues shorter than that of the monkey protein. Northern blot analysis revealed ubiquitous expression of a 4.4-kb HAVCR1 transcript, with highest levels in kidney and testis. An additional 5.5-kb transcript was detected in colon and liver, while spleen, thymus, and peripheral blood leukocytes expressed an additional 7.5-kb transcript. Western blot analysis showed expression of a 53-kD protein.

TIM-1/KIM-1 protein family

Belongs to the immunoglobulin superfamily. TIM family.

TIM-1/KIM-1 protein name

Recommended name
Hepatitis A virus cellular receptor 1
Short name
CD365, HAVCR, HAVCR-1, kidney injury molecule 1, KIM1, T-cell immunoglobulin mucin family member 1, TIM1, TIM-1, TIMD1
Alternative name
Kidney injury molecule 1 T-cell immunoglobulin and mucin domain-containing protein 1 T-cell immunoglobulin mucin receptor 1 T-cell membrane protein 1

TIM-1/KIM-1 Gene family protein

TIM-1/KIM-1 Protein Sequence

Species Human TIM-1/KIM-1 protein
Length 359
Mass (Da) 38720
Sequence Human TIM-1/KIM-1 protein sequence
Species Mouse TIM-1/KIM-1 protein
Length 305
Mass (Da) 33361
Sequence Mouse TIM-1/KIM-1 protein sequence
Species Rat TIM-1/KIM-1 protein
Length 307
Mass (Da) 33964
Sequence Rat TIM-1/KIM-1 protein sequence

TIM-1/KIM-1 Protein Molecular Weight & PI

Hepatitis A virus cellular receptor 1 precursor (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell immunoglobulin mucin receptor 1) (TIM) (TIM-1) (T-cell membrane protein 1) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 21-359 Hepatitis A virus cellular receptor 1.

Molecular weight (Da)


Theoretical pI


TIM-1/KIM-1 Protein Structure

Crystal structure of human T-cell immunoglobulin and mucin domain protein 1
2015-09-25   Released:  2015-11-25
Deposition Author(s)
Yuan, S., Rao, Z., Wang, X.
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
1.3010 Å
R-Value Free
R-Value Work

Human TIM-1/KIM-1 protein Secondary structure

TIM-1/KIM-1 Protein Interaction

Recombinant TIM-1/KIM-1 Protein Feature

TIM-1/KIM-1 Protein, Mouse, Recombinant (hHis & Fc Tag)

High Purity
> 97 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant TIM-1/KIM-1 protein citations

Accelerated Receptor Shedding Inhibits Kidney Injury Molecule-1 (KIM-1)-mediated Efferocytosis
Gandhi, R;Yi, J;Ha, J;Shi, H;Ismail, O;Nathoo, S;Bonventre, JV;Zhang, X;Gunaratnam, L;
Am. J. Physiol. Renal Physiol.
Environmental Stability of Plasmonic Biosensors based on Natural vs. Artificial Antibody
Luan, J;Xu, T;Cashin, J;Morrissey, JJ;Kharasch, ED;Singamaneni, S;
Anal. Chem.
Exosomes exploit the virus entry machinery and pathway to transmit IFN-α-induced antiviral activity.
Yao, Z;Li, X;Chen, J;Qiao, Y;Shen, F;Shi, B;Liu, J;Ding, J;Peng, L;Li, J;Yuan, Z;

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