TIGIT Information: TIGIT Protein, TIGIT Antibody and TIGIT Gene

TIGIT Gene family

TIGIT Protein

TIGIT protein function

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. {ECO:0000269|PubMed:19011627}.

TIGIT protein expression

Tissue specificity

Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level).

TIGIT protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    244.00
  • Mass (KDa)
    26.00

TIGIT Antibody

There are 5 TIGIT antibodies which are validated in multiple tissues with various applications, including ELISA, IHC-P. There are 5 TIGIT antibody for ELISA, 1 TIGIT antibody for IHC-P. Among all these TIGIT antibodies, there are 1 anti-TIGIT mouse monoclonal antibodies , 4 anti-TIGIT rabbit polyclonal antibodies . All the TIGIT anbodies are produced in house and all are in stock. TIGIT antibody customerized service is available.

TIGIT Gene

TIGIT gene / cDNA is a protein-coding gene which located on 3q13.31. The TIGIT gene is conserved in chimpanzee, dog, cow, mouse, and rat.123 organisms have orthologs with human gene TIGIT.