SSH3BP1 Protein Overview: Sequence, Structure, Function and Protein Interaction

SSH3BP1 Protein Overview

SSH3BP1 reagents

Taki et al. (1998) identified the ABI1 gene as the fusion partner with MLL (159555) in a patient with acute myeloid leukemia (AML) and a t(10;11)(p11.2;q23) ABI1 is a human homolog of mouse Abl-interactor-1 (Abi1). The ABI1 protein exhibited sequence similarity to protein of homeotic genes, contained several polyproline stretches, and included a Src homology-3 (SH3) domain at the C terminus that is required for binding of mouse Abi1 protein to Abl proteins. Three types of the ABI1 gene were expressed in normal peripheral blood. The MLL-ABI1 fusion transcript in this patient was formed by an alternatively spliced ABI1. In-frame MLL-ABI1 fusion transcripts combined the MLL AT-hook motifs and DNA methyltransferase homology region with the homeodomain homologous region, polyproline stretches, and SH3 domain of the alternatively spliced transcript of ABI1. The results suggested that ABI1 plays a role in the leukemogenesis by translocating to MLL. Taki et al. (1998) noted the similarity between the protein they described and the E3B1 protein described by Biesova et al. (1997), which was also isolated as a human homolog of mouse Abi1.

SSH3BP1 protein family

Belongs to the ABI family.

SSH3BP1 protein name

Recommended name
Abl interactor 1
Aliases
ABI-1, E3B1

SSH3BP1 Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 2-508 Abl interactor 1.

Molecular weight (Da)

54949.65

Theoretical pI

6.61

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