SIRP alpha Information: SIRP alpha Protein, SIRP alpha Antibody and SIRP alpha Gene

SIRP alpha Gene family

SIRP alpha Protein

SIRP alpha protein function

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. {ECO:0000250, ECO:0000269|PubMed:10469599, ECO:0000269|PubMed:11509594}.

SIRP alpha protein expression

Tissue specificity

Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.

SIRP alpha protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (KDa)

SIRP alpha Antibody

There are 23 SIRP alpha antibodies which are validated in multiple tissues with various applications, including ELISA, FCM, IP, WB, IHC-P. There are 10 SIRP alpha antibody for ELISA, 15 SIRP alpha antibody for FCM, 1 SIRP alpha antibody for IP, 1 SIRP alpha antibody for WB, 1 SIRP alpha antibody for IHC-P. Among all these SIRP alpha antibodies, there are 4 anti-SIRP alpha mouse monoclonal antibodies , 6 anti-SIRP alpha rabbit polyclonal antibodies , 13 anti-SIRP alpha rabbit monoclonal antibodies . All the SIRP alpha anbodies are produced in house and all are in stock. SIRP alpha antibody customerized service is available.

SIRP alpha Gene

SIRPA gene / cDNA is a protein-coding gene which located on 20p13. The SIRPA gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.93 organisms have orthologs with human gene SIRPA.