RET Protein Overview: Sequence, Structure, Function and Protein Interaction

RET Protein Overview


RET protein family

Belongs to the protein kinase superfamily. Tyr protein kinase family.

RET protein name

Recommended name
Proto-oncogene tyrosine-protein kinase receptor Ret
cadherin-related family member 16, CDHF12, CDHR16, PTC, rearranged during transfection, RET receptor tyrosine kinase, RET51
Alternative name
Cadherin family member 12 Proto-oncogene c-Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment

RET Protein Sequence

Species Human RET protein
Length 1114
Mass (Da) 124319
Sequence Human RET protein sequence
Species Mouse RET protein
Length 1115
Mass (Da) 123874
Sequence Mouse RET protein sequence
Species Rat RET protein
Length 1115
Mass (Da) 124237
Sequence Rat RET protein sequence

RET Protein Molecular Weight & PI

Proto-oncogene tyrosine-protein kinase receptor Ret precursor (EC (Cadherin family member 12) (Proto-oncogene c-Ret) [Contains: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 29-1114 Proto-oncogene tyrosine-protein kinase

Molecular weight (Da)


Theoretical pI


RET Protein Structure

Crystal structure of non-phosphorylated RET tyrosine kinase domain
2006-06-16   Released:  2006-08-14
Deposition Author(s)
Knowles, P.P., Murray-Rust, J., McDonald, N.Q.
Homo sapiens
Expression System
Spodoptera frugiperda
Experimental Data Snapshot
2.0000 Å
R-Value Free
R-Value Work

Human RET protein Secondary structure

RET Protein Interaction

Recombinant RET Protein Feature

RET Protein, Human, Recombinant (His Tag)

High Purity
> 92 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

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