RAGE Protein Overview: Sequence, Structure, Function and Protein Interaction

RAGE Protein Overview

Sugaya et al. (1994) identified 3 genes, AGER, PBX2 (176311), and NOTCH4 (164951), located 90 to 140 kb centromeric to the tenascin-like gene (600985) in the MHC class III region near the junction with class II. AGER is a member of the immunoglobulin superfamily.

RAGE protein name

Recommended name
Advanced glycosylation end product-specific receptor
RAGE, receptor for advanced glycation end-products, SCARJ1
Alternative name
Receptor for advanced glycosylation end products

RAGE Gene family protein

RAGE Protein Sequence

Species Human RAGE protein
Length 404
Mass (Da) 42803
Sequence Human RAGE protein sequence
Species Mouse RAGE protein
Length 402
Mass (Da) 42654
Sequence Mouse RAGE protein sequence
Species Rat RAGE protein
Length 402
Mass (Da) 42664
Sequence Rat RAGE protein sequence

RAGE Protein Molecular Weight & PI

Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 23-404 Advanced glycosylation end product-

Molecular weight (Da)


Theoretical pI


RAGE Protein Structure

Crystal structure of the human RAGE VC1 fragment in space group P62
2013-07-15   Released:  2013-10-16
Deposition Author(s)
Yatime, L., Andersen, G.R.
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
2.4000 Å
R-Value Free
R-Value Work
4LP4 From PDB

Human RAGE protein Secondary structure

RAGE Protein Interaction

Recombinant RAGE Protein Feature

RAGE Protein, Human, Recombinant

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant RAGE protein citations

The receptor for advanced glycation end products mediates lung endothelial activation by RBCs
NS Mangalmurti, JL Friedman…
American Journal of Physiol Lung Cell Mol Physiol
A Novel, Multi-Target Natural Drug Candidate, Matrine, Improves Cognitive Deficits in Alzheimer's Disease Transgenic Mice by Inhibiting Aβ Aggregation and Blocking the RAGE/Aβ Axis
Cui, L;Cai, Y;Cheng, W;Liu, G;Zhao, J;Cao, H;Tao, H;Wang, Y;Yin, M;Liu, T;Liu, Y;Huang, P;Liu, Z;Li, K;Zhao, B;
Mol. Neurobiol.
Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice
Stark, K;Philippi, V;Stockhausen, S;Busse, J;Antonelli, A;Miller, M;Schubert, I;Hoseinpour, P;Chandraratne, S;von Brühl, ML;Gaertner, F;Lorenz, M;Agresti, A;Coletti, R;Antoine, DJ;Heermann, R;Jung, K;Reese, S;Laitinen, I;Schwaiger, M;Walch, A;Sperandio, M;Nawroth, PP;Reinhardt, C;Jäckel, S;Bianchi, ME;Massberg, S;
The C-terminal tails of 4,4'-diphenylmethane-bis(methyl) carbamate are essential for binding to receptor for advanced glycation end products to attenuate advanced glycation end products-induced inflammation and apoptosis responses in human umbilical vein endothelial cells
Feng, L;Zhu, MM;Bu, WQ;Wang, CF;Zheng, ZG;Wang, RS;Jia, XB;Zhu, Q;
J. Pharm. Pharmacol.

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