RAGE Information: RAGE Protein, RAGE Antibody and RAGE Gene

RAGE Gene family

RAGE Protein

RAGE protein function

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. {ECO:0000250, ECO:0000269|PubMed:19906677, ECO:0000269|PubMed:20943659, ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:21565706}.

RAGE protein expression

Tissue specificity

Endothelial cells.

RAGE protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    404.00
  • Mass (KDa)
    42.00

RAGE Antibody

There are 11 RAGE antibodies which are validated in multiple tissues with various applications, including WB, IHC-P, ELISA. There are 3 RAGE antibody for WB, 4 RAGE antibody for IHC-P, 8 RAGE antibody for ELISA. Among all these RAGE antibodies, there are 8 anti-RAGE rabbit polyclonal antibodies , 2 anti-RAGE mouse monoclonal antibodies , 1 anti-RAGE rabbit monoclonal antibodies . All the RAGE anbodies are produced in house and all are in stock. RAGE antibody customerized service is available.

RAGE Gene

AGER gene / cDNA is a protein-coding gene which located on 6p21.32. The AGER gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.116 organisms have orthologs with human gene AGER.