PTOP Protein Overview: Sequence, Structure, Function and Protein Interaction

PTOP Protein Overview

PTOP reagents

By database analysis and RT-PCR of HeLa cell mRNA, Liu et al. (2004) cloned PTOP. The deduced 544-amino acid protein contains a pro-trp-ile (PWI) motif, followed by a central POT1 (606478) recruitment domain and a serine-rich region. Compared with bovine, mouse, and pufferfish Ptop, human PTOP has an additional 86 N-terminal amino acids. By database analysis, Liu et al. (2004) identified 2 PTOP splice variants with in-frame deletions that encode proteins with deletions in the PWI domain or following the serine-rich region. PTOP was expressed in all human tissues examined. Immunofluorescence microscopy detected PTOP in a punctate pattern that colocalized with telomere proteins.

PTOP protein name

Recommended name
Adrenocortical dysplasia protein homolog
Pip1, POT1 and TIN2 organizing protein, Ptop, TIN2 interacting protein 1, Tint1, Tpp1

PTOP Gene family protein

Shelterin complex
Approved symbol Common name
TERF1 TRF1 protein, recombinant

PTOP Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 1-544 Adrenocortical dysplasia protein homolog.

Molecular weight (Da)


Theoretical pI


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