PD-L1 Information: PD-L1 Protein, PD-L1 Antibody and PD-L1 Gene

PD-L1 Gene family

PD-L1 Protein

PD-L1 protein function

Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}.

PD-L1 protein expression

Tissue specificity

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

Induction

Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking.

PD-L1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    290.00
  • Mass (KDa)
    33.00

PD-L1 Antibody

There are 37 PD-L1 antibodies which are validated in multiple tissues with various applications, including IHC-P, ELISA, WB, FCM, ELISA(Cap), ELISA(Det), Neutralization, ICC/IF, IP. There are 3 PD-L1 antibody for IHC-P, 16 PD-L1 antibody for ELISA, 2 PD-L1 antibody for WB, 16 PD-L1 antibody for FCM, 1 PD-L1 antibody for ELISA(Cap), 1 PD-L1 antibody for ELISA(Det), 1 PD-L1 antibody for Neutralization, 1 PD-L1 antibody for ICC/IF, 1 PD-L1 antibody for IP. Among all these PD-L1 antibodies, there are 11 anti-PD-L1 mouse monoclonal antibodies , 16 anti-PD-L1 rabbit monoclonal antibodies , 10 anti-PD-L1 rabbit polyclonal antibodies . All the PD-L1 anbodies are produced in house and all are in stock. PD-L1 antibody customerized service is available.

PD-L1 Gene

CD274 gene / cDNA is a protein-coding gene which located on 9p24.1. The CD274 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.160 organisms have orthologs with human gene CD274.