Osteoprotegerin Protein Overview: Sequence, Structure, Function and Protein Interaction

Osteoprotegerin Protein Overview

Osteoprotegerin protein name

Recommended name
Tumor necrosis factor receptor superfamily member 11B
Alternative name
Osteoclastogenesis inhibitory factor Osteoprotegerin

Osteoprotegerin Protein Sequence

Species Human Osteoprotegerin protein
Length 401
Mass (Da) 46026
Sequence Human Osteoprotegerin protein sequence
Species Mouse Osteoprotegerin protein
Length 401
Mass (Da) 45923
Sequence Mouse Osteoprotegerin protein sequence
Species Rat Osteoprotegerin protein
Length 401
Mass (Da) 46192
Sequence Rat Osteoprotegerin protein sequence

Osteoprotegerin Protein Molecular Weight & PI

Tumor necrosis factor receptor superfamily member 11B precursor (Osteoclastogenesis inhibitory factor) (Osteoprotegerin) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 22-401 Tumor necrosis factor receptor

Molecular weight (Da)


Theoretical pI


Osteoprotegerin Protein Structure

Human RANKL/OPG complex
2011-11-22   Released:  2012-07-11
Deposition Author(s)
Wang, X.Q., Luan, X.D., Lu, Q.Y.
Homo sapiens
Expression System
Escherichia coli, Spodoptera frugiperda
Experimental Data Snapshot
2.7010 Å
R-Value Free
R-Value Work

Human Osteoprotegerin protein Secondary structure

Osteoprotegerin Protein Interaction

Recombinant Osteoprotegerin Protein Feature

Osteoprotegerin Protein, Human, Recombinant (His Tag)

High Purity
> 97 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its binding ability in a functional ELISA. Immobilized human TNFRSF11B-His at 10 μg/ml (100 μl/well) can bind human Fc-TNFSF11 (Cat:11682-H01H) with a linear range of 125-200 ng/mL.

Recombinant Osteoprotegerin protein citations

A versatile method for protein-based antigen bioanalysis in non-clinical pharmacokinetics studies of a human monoclonal antibody drug by an immunoaffinity liquid chromatography-tandem mass spectrometry
Onami, I;Ayabe, M;Murao, N;Ishigai, M;
J Chromatogr A

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