Osteoprotegerin Gene Sequence, Family, Fuction and Expression Information

Osteoprotegerin cDNA / Gene Overview

TNFRSF11B gene / cDNA is a protein-coding gene which located on 8q24.12. The TNFRSF11B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.218 organisms have orthologs with human gene TNFRSF11B.

Osteoprotegerin cDNA / Gene Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Osteoprotegerin cDNA / Gene Sequence

LOCUS
LOCUS NM_002546 2354 bp mRNA linear PRI 12-AUG-2018
DEFINITION
Homo sapiens TNF receptor superfamily member 11b (TNFRSF11B), mRNA.
ACCESSION
NM_002546
VERSION
NM_002546.3

This sequence information is just for reference only.

Osteoprotegerin Family & Reagents

Osteoprotegerin Gene family reagents (Tumor necrosis factor receptor superfamily)

Approved Symbol Reagent list
TNFRSF13B
RELT
TNFRSF10B
CD27
TNFRSF25
TNFRSF1B
TNFRSF10A
TNFRSF8
TNFRSF4
LTBR
Approved Symbol Reagent list
TNFRSF13C
TNFRSF14
TNFRSF1A
CD40
TNFRSF10D
EDA2R
EDAR
FAS
TNFRSF19
TNFRSF10C

Osteoprotegerin cDNA / Gene Alias

  • OCIF
  • TR1

Osteoprotegerin cDNA / Gene Expression

Biased expression in thyroid (RPKM 62.5), kidney (RPKM 16.2) and 7 other tissues