NOTCH1 Protein Overview: Sequence, Structure, Function and Protein Interaction

NOTCH1 Protein Overview

Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development. The Notch family includes 4 receptors, NOTCH1, NOTCH2 (600275), NOTCH3 (600276), and NOTCH4 (164951), whose ligands include JAG1 (601920), JAG2 (602570), DLL1 (606582), DLL3 (602768), and DLL4 (605185). All of the receptors have an extracellular domain containing multiple epidermal growth factor (EGF; 131530)-like repeats and an intracellular region containing the RAM domain, ankyrin repeats, and a C-terminal PEST domain (Das et al., 2004).

NOTCH1 protein family

Belongs to the NOTCH family.

NOTCH1 protein name

Recommended name
Neurogenic locus notch homolog protein 1
Short name
Notch 1||hN1
Alternative name
Translocation-associated notch protein TAN-1 Notch 1 extracellular truncation Notch 1 intracellular domain

NOTCH1 Protein Sequence

Species Human NOTCH1 protein
Length 2555
Mass (Da) 272505
Sequence Human NOTCH1 protein sequence
Species Mouse NOTCH1 protein
Length 2531
Mass (Da) 270835
Sequence Mouse NOTCH1 protein sequence
Species Rat NOTCH1 protein
Length 2531
Mass (Da) 270822
Sequence Rat NOTCH1 protein sequence

NOTCH1 Protein Molecular Weight & PI

Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 19-2555 Neurogenic locus notch homolog protein 1.

Molecular weight (Da)


Theoretical pI


NOTCH1 Protein Structure

Crystal structure of the human Notch 1 ankyrin domain
2005-02-25   Released:  2005-08-16
Deposition Author(s)
Ehebauer, M.T., Chirgadze, D.Y., Hayward, P., Martinez-Arias, A., Blundell, T.L.
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
1.9010 Å
R-Value Free
R-Value Work

Human NOTCH1 protein Secondary structure

NOTCH1 Protein Interaction

Recombinant NOTCH1 Protein Feature

NOTCH1 Protein, Mouse, Recombinant (ECD, hFc Tag)

High Purity
> 90 % as determined by SDS-PAGE.
Low Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.

Recombinant NOTCH1 protein citations

Both Notch1 and its ligands in B cells promote antibody production
Zhu, G;Wang, X;Xiao, H;Liu, X;Fang, Y;Zhai, B;Xu, R;Han, G;Chen, G;Hou, C;Shen, B;Li, Y;Ma, N;Wu, H;Liu, G;Wang, R;
Mol. Immunol.

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