NFkB1/p105 Gene Sequence, Family, Fuction and Expression Information
NFkB1/p105 cDNA / Gene Overview
NFKB1 cDNA / gene is a gene with protein product which located on 4q24. The NFKB1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. 224 organisms have orthologs with human gene NFKB1.
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]
NFkB1/p105 cDNA / Gene Sequence
HUMNFKB 3625 bp mRNA linear PRI 27-APR-1993
Human nuclear factor kappa-B DNA binding subunit (NF-kappa-B) mRNA, complete cds.
This sequence information is just for reference only.
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