NFkB1/p105 Information: NFkB1/p105 Protein, NFkB1/p105 Antibody and NFkB1/p105 Gene

NFkB1/p105 Gene family

NFkB1/p105 Protein

NFkB1/p105 protein function

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.

NFkB1/p105 protein expression

Induction

By phorbol ester and TNF.

NFkB1/p105 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    968.00
  • Mass (KDa)
    105.00

NFkB1/p105 Antibody

There are 1 NFkB1/p105 antibodies which are validated in multiple tissues with various applications, including WB, ICC/IF. There are 1 NFkB1/p105 antibody for WB, 1 NFkB1/p105 antibody for ICC/IF. Among all these NFkB1/p105 antibodies, there are 1 anti-NFkB1/p105 rabbit polyclonal antibodies . All the NFkB1/p105 anbodies are produced in house and all are in stock. NFkB1/p105 antibody customerized service is available.

NFkB1/p105 Gene

NFKB1 cDNA / gene is a gene with protein product which located on 4q24. The NFKB1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. 224 organisms have orthologs with human gene NFKB1.