NCAM Gene Sequence, Family, Fuction and Expression Information

NCAM cDNA / Gene Overview

NCAM1 gene / cDNA is a protein-coding gene which located on 11q23.2. The NCAM1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.227 organisms have orthologs with human gene NCAM1.

NCAM cDNA / Gene Function

This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

NCAM cDNA / Gene Sequence

LOCUS
LOCUS NM_000615 5977 bp mRNA linear PRI 12-AUG-2018
DEFINITION
Homo sapiens neural cell adhesion molecule 1 (NCAM1), transcript variant 1, mRNA.
ACCESSION
NM_000615
VERSION
NM_000615.6

This sequence information is just for reference only.

NCAM Family & Reagents

NCAM Gene family reagents (CD molecules)

Approved Symbol Reagent list
CD46
FCGR3B
IL1R2
GYPA
IFNGR1
CD52
IL18RAP
CD37
CDH2
NGFR
Approved Symbol Reagent list
CD84
CD68
CLEC12A
TNFRSF1A
SIRPG
IL13Ra1
CD82
FASLG
CD320
INSR

NCAM Gene family reagents (Fibronectin type III domain containing)

Approved Symbol Reagent list
ROBO4
MERTK
IL7R
EphB2
IL31RA
IL12RB1
EPHA8
FLRT1
AXL
CDON
Approved Symbol Reagent list
CNTN6
INSR
NFASC
IL2RG
IL6ST
CHL1
EphB6
CNTN3
ROBO2
CNTFR

NCAM Gene family reagents (I-set domain containing)

Approved Symbol Reagent list
NECTIN3
ROR2
MUSK
SPEG
FSTL5
MDGA2
LRIG1
FLT1
IGSF11
CLMP
Approved Symbol Reagent list
VSIG2
NPTN
MFAP3
NTRK2
MAG
MERTK
CADM2
NRG2
IL1RAPL1
ADAMTSL1

NCAM Gene family reagents (Ig-like cell adhesion molecule family)

Approved Symbol Reagent list
CNTN6
NECTIN1
SLAMF6
NCAM2
PECAM1
BCAM
FGFRL1
CADM4
VCAM1
CADM1
Approved Symbol Reagent list
SIRPA
PVR
CNTN5
NFASC
L1CAM
CNTN3
ICAM1
ALCAM
JAML
CD96

NCAM cDNA / Gene Alias

  • CD56
  • NCAM

NCAM cDNA / Gene Expression

Biased expression in brain (RPKM 90.3), adrenal (RPKM 31.4) and 6 other tissues

Recombinant NCAM protein citations

Title
Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor
Year
2020
Author
Srivastava, M;Zhang, Y;Chen, J;Sirohi, D;Miller, A;Zhang, Y;Chen, Z;Lu, H;Xu, J;Kuhn, RJ;Andy Tao, W;
Journal
Nat Commun