N Cadherin Protein Overview: Sequence, Structure, Function and Protein Interaction

N Cadherin Protein Overview

Reid and Hemperly (1990) obtained a full-length NCAD clone from a Kelly neuroblastoma library. The NCAD gene encodes a 907-amino acid protein that includes a 159-amino acid signal sequence. Human and mouse nucleotide sequences are 96% identical.

N Cadherin protein name

Recommended name
CD325, CDHN, N-cadherin
Alternative name
CDw325 Neural cadherin N-cadherin CD antigen CD325

N Cadherin Protein Sequence

Species Human N Cadherin protein
Length 906
Mass (Da) 99809
Sequence Human N Cadherin protein sequence
Species Mouse N Cadherin protein
Length 906
Mass (Da) 99796
Sequence Mouse N Cadherin protein sequence
Species Rat N Cadherin protein
Length 906
Mass (Da) 99686
Sequence Rat N Cadherin protein sequence

N Cadherin Protein Molecular Weight & PI

Cadherin-2 precursor (CDw325) (Neural cadherin) (N-cadherin) (CD325 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 160-906 Cadherin-2.

Molecular weight (Da)


Theoretical pI


N Cadherin Protein Interaction

Recombinant N Cadherin Protein Feature

N Cadherin Protein, Human, Recombinant (His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by the ability of the immobilized protein to support the adhesion of MCF-7 human breast adenocarcinoma cells. When 5 x 104 cells/well are added to CDH2 coated plates (10 μg/mL with 100 μL/well), approximately 60% will adhere after 1 hour at 37℃.

Recombinant N Cadherin protein citations

The Xin repeat-containing protein, mXinβ, initiates the maturation of the intercalated discs during postnatal heart development
Wang, Q;Lin, JL;Chan, SY;Lin, JJ;
Dev. Biol.
A fully human scFv phage display library for rapid antibody fragment reformatting
Li, K;Zettlitz, KA;Lipianskaya, J;Zhou, Y;Marks, JD;Mallick, P;Reiter, RE;Wu, AM;
Protein Eng. Des. Sel.
Degradome of soluble ADAM10 and ADAM17 metalloproteases
Scharfenberg, F;Helbig, A;Sammel, M;Benzel, J;Schlomann, U;Peters, F;Wichert, R;Bettendorff, M;Schmidt-Arras, D;Rose-John, S;Moali, C;Lichtenthaler, SF;Pietrzik, CU;Bartsch, JW;Tholey, A;Becker-Pauly, C;
Cell. Mol. Life Sci.

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