MAPK11 Protein Overview: Sequence, Structure, Function and Protein Interaction

MAPK11 Protein Overview

Mitogen-activated protein kinase (MAPK) cascades represent one of the major signal systems used by eukaryotic cells to transduce extracellular signals into cellular responses. Four MAPK subgroups have been identified in humans: the extracellular signal-regulated kinases (ERKs), the c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPKs), the ERK5/BMK protein (602521), and the p38 MAP kinases. MAPKs are activated by dual-specificity MAPK kinases (MAPKKs; see 602425).

MAPK11 protein family

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

MAPK11 protein name

Recommended name
Mitogen-activated protein kinase 11
Short name
MAP kinase 11||MAPK 11||MAP kinase p38 beta||
p38-2, p38Beta, SAPK2
Alternative name
Mitogen-activated protein kinase p38 beta Stress-activated protein kinase 2b p38-2

MAPK11 Protein Sequence

Species Human MAPK11 protein
Length 364
Mass (Da) 41357
Sequence Human MAPK11 protein sequence
Species Mouse MAPK11 protein
Length 364
Mass (Da) 41397
Sequence Mouse MAPK11 protein sequence
Mass (Da)

MAPK11 Protein Molecular Weight & PI

Mitogen-activated protein kinase 11 (EC (MAP kinase 11) (MAPK 11) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-364 Mitogen-activated protein kinase 11.

Molecular weight (Da)


Theoretical pI


MAPK11 Protein Structure

The structure of p38beta C119S, C162S in complex with a dihydroquinazolinone inhibitor
2009-02-21   Released:  2009-07-21
Deposition Author(s)
Scapin, G., Patel, S.B.
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
2.0500 Å
R-Value Free
R-Value Work
3GC9 From PDB

Human MAPK11 protein Secondary structure

MAPK11 Protein Interaction

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