Lyn Protein Overview: Sequence, Structure, Function and Protein Interaction

Lyn Protein Overview

Lyn reagents

Using a v-yes DNA as the probe, Yamanashi et al. (1987) screened a human cDNA library made from placental RNA and derived DNA clones representing a novel genetic locus termed LYN. Nucleotide sequencing showed that LYN encodes a novel tyrosine kinase. Northern hybridization analysis showed that a 3.2-kb LYN mRNA was expressed in a variety of tissues of the human fetus. The pattern of expression was different from those of related genes such as YES (164880).

Lyn protein family

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Lyn protein name

Recommended name
Tyrosine-protein kinase Lyn
Aliases
JTK8
Alternative name
Lck/Yes-related novel protein tyrosine kinase V-yes-1 Yamaguchi sarcoma viral related oncogene homolog p53Lyn p56Lyn

Lyn Protein Sequence

Species Human Lyn protein
Length 512
Mass (Da) 58574
Sequence Human Lyn protein sequence
Species Mouse Lyn protein
Length 512
Mass (Da) 58812
Sequence Mouse Lyn protein sequence
Species Rat Lyn protein
Length 512
Mass (Da) 58660
Sequence Rat Lyn protein sequence

Lyn Protein Molecular Weight & PI

Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 2-512 Tyrosine-protein kinase Lyn.

Molecular weight (Da)

58442.89

Theoretical pI

6.76

Lyn Protein Structure

Crystal structure of Lyn kinase domain in complex with N-(1H-indazol-6-yl)-8-(piperidin-4-yloxy)-6-propylquinazolin-2-amine
Deposited
2017-07-05   Released:  2017-08-02
Deposition Author(s)
Kim, H.T.
Organism(s)
Homo sapiens
Expression System
Insect cell expression vector pTIE1
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.7000 Å
R-Value Free
0.260
R-Value Work
0.214
5XY1 From PDB

Human Lyn protein Secondary structure

Lyn Protein Interaction

Recombinant Lyn Protein Feature

Lyn Protein, Human, Recombinant (GST Tag)

High Purity
> 94 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
The specific activity was determined to be 30 nmol/min/mg using Poly(Glu,Tyr) 4:1 as substrate.

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