KIRREL2 Gene Sequence, Family, Fuction and Expression Information

KIRREL2 cDNA / Gene Overview

KIRREL2 gene / cDNA is a protein-coding gene which located on 19q13.12. The KIRREL2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.151 organisms have orthologs with human gene KIRREL2.

KIRREL2 cDNA / Gene Function

This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]

KIRREL2 cDNA / Gene Sequence

LOCUS
LOCUS NM_032123 2582 bp mRNA linear PRI 30-JUN-2018
DEFINITION
Homo sapiens kirre like nephrin family adhesion molecule 2 (KIRREL2), transcript variant 1, mRNA.
ACCESSION
NM_032123
VERSION
NM_032123.6

This sequence information is just for reference only.

KIRREL2 Family & Reagents

KIRREL2 Gene family reagents (C2-set domain containing)

Approved Symbol Reagent list
ICOSLG
MCAM
CADM3
NECTIN3
KIRREL3
NECTIN1
PVR
ALCAM
NECTIN4
CD22
Approved Symbol Reagent list
CD2
CD200R1L
TMEM25
CD200R1
BTN3A1
CD80
CD274
VCAM1
CADM2
CADM4

KIRREL2 Gene family reagents (I-set domain containing)

Approved Symbol Reagent list
MERTK
WFIKKN2
ROR1
NPTN
ROBO4
HepaCAM2
CNTN4
VSIG2
ROR2
KDR
Approved Symbol Reagent list
L1CAM
FGFRL1
CNTN2
NRG2
VCAM1
ROBO2
NCAM1
CLMP
SIGLEC6
NTM

KIRREL2 Gene family reagents (Immunoglobulin like domain containing)

Approved Symbol Reagent list
FCER1A
SIGIRR
PVR
CD84
CADM1
FCRL2
ICAM5
CEACAM1
CADM4
FCGR2B
Approved Symbol Reagent list
CNTN4
IL1RAPL1
JAM3
IGSF3
MERTK
FLT3
IL1R2
ICAM4
MUSK
IL1RAP

KIRREL2 cDNA / Gene Alias

  • DKFZp564A1164
  • FILTRIN
  • MGC15718
  • NEPH3
  • NLG1

KIRREL2 cDNA / Gene Expression

Biased expression in pancreas (RPKM 5.8), kidney (RPKM 0.6) and 3 other tissues