Jagged 1 Gene Sequence, Family, Fuction and Expression Information

Jagged 1 cDNA / Gene Overview

JAG1 gene / cDNA is a protein-coding gene which located on 20p12.2. The JAG1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.236 organisms have orthologs with human gene JAG1.

Jagged 1 cDNA / Gene Function

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]

Jagged 1 cDNA / Gene Sequence

LOCUS
LOCUS NM_000214 5940 bp mRNA linear PRI 28-JUL-2018
DEFINITION
Homo sapiens jagged 1 (JAG1), mRNA.
ACCESSION
NM_000214
VERSION
NM_000214.3

This sequence information is just for reference only.

Jagged 1 Family & Reagents

Gene family

Jagged 1 Gene family reagents (CD molecules)

Approved Symbol Reagent list
KLRK1
CD1B
CD52
SIRPG
CD300C
CSF1R
TNFSF13
TNFRSF10C
F3
CD14
Approved Symbol Reagent list
THY1
TNFRSF1B
LAIR1
SELP
CD34
TLR4
BTLA
INSR
ICAM1
CD274

Jagged 1 cDNA / Gene Alias

  • AHD
  • AWS
  • CD339
  • HJ1

Jagged 1 cDNA / Gene Expression

Ubiquitous expression in placenta (RPKM 27.7), skin (RPKM 22.8) and 24 other tissues

Recombinant Jagged 1 protein citations

Title
The impact of parathyroid hormone treated mesenchymal stem cells on ex-vivo expansion of cord blood hematopoietic stem cells
Year
2019
Author
Esmaeili, M;Niazi, V;Pourfathollah, A;Mousavi Hosseini, M;Nakhlestani, M;Golzadeh, K;Taheri, M;Ghafouri-Fard, S;Atarodi, K;
Journal
Gene Reports