Jagged 1 Gene Sequence, Family, Fuction and Expression Information
Jagged 1 cDNA / Gene Overview
JAG1 gene / cDNA is a protein-coding gene which located on 20p12.2. The JAG1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.236 organisms have orthologs with human gene JAG1.
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
Jagged 1 cDNA / Gene Sequence
LOCUS NM_000214 5940 bp mRNA linear PRI 28-JUL-2018
Homo sapiens jagged 1 (JAG1), mRNA.
This sequence information is just for reference only.
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