IRG1/immune-responsive gene 1 Protein Overview: Sequence, Structure, Function and Protein Interaction

IRG1/immune-responsive gene 1 Protein Overview

IRG1/immune-responsive gene 1 reagents

Xiao et al. (2011) found that the predicted human IRG1 protein is highly homologous to Irg1 proteins in chicken and various other mammals. By RT-PCR of human fetal tissues, they detected IRG1 expression in peripheral blood mononuclear cells (PBMCs) only. IRG1 expression in adult PBMCs increased rapidly 18 hours after stimulation with lipopolysaccharide (LPS), but IRG1 showed little to no expression before this time point or 24 hours after stimulation. IRG1 expression was not detected in unstimulated or LPS-stimulated leukemia cell lines. Immunoblot analysis revealed a protein of about 80 kD, likely representing full-length IRG1, in unstimulated fetal PBMCs and in adult PBMCs 18 after LPS stimulation, with lower expression in adult PBMCs 24 hours after LPS stimulation.

IRG1/immune-responsive gene 1 protein family

Belongs to the PrpD family.

IRG1/immune-responsive gene 1 protein name


IRG1/immune-responsive gene 1 Protein Molecular Weight & PI

The parameters have been computed for the following feature

FT CHAIN 1-481 Cis-aconitate decarboxylase

Molecular weight (Da)


Theoretical pI


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