Integrin alpha 3 Information: Integrin alpha 3 Protein, Integrin alpha 3 Antibody and Integrin alpha 3 Gene

Integrin alpha 3 Gene family

Integrin alpha 3 Protein

Integrin alpha 3 protein function

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. {ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:15181153}.

Integrin alpha 3 protein expression

Tissue specificity

Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells.

Integrin alpha 3 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,051.00
  • Mass (KDa)
    116.00

Integrin alpha 3 Antibody

There are 3 Integrin alpha 3 antibodies which are validated in multiple tissues with various applications, including IHC-P, WB. There are 2 Integrin alpha 3 antibody for IHC-P, 1 Integrin alpha 3 antibody for WB. Among all these Integrin alpha 3 antibodies, there are 3 anti-Integrin alpha 3 rabbit polyclonal antibodies . All the Integrin alpha 3 anbodies are produced in house and all are in stock. Integrin alpha 3 antibody customerized service is available.

Integrin alpha 3 Gene

ITGA3 gene / cDNA is a protein-coding gene which located on 17q21.33. The ITGA3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.193 organisms have orthologs with human gene ITGA3.