Integrin alpha 2 Gene Sequence, Family, Fuction and Expression Information

Integrin alpha 2 cDNA / Gene Overview

ITGA2 gene / cDNA is a protein-coding gene which located on 5q11.2. The ITGA2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.233 organisms have orthologs with human gene ITGA2.

Integrin alpha 2 cDNA / Gene Function

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Integrin alpha 2 cDNA / Gene Sequence

LOCUS
LOCUS NM_002203 7878 bp mRNA linear PRI 08-JUL-2018
DEFINITION
Homo sapiens integrin subunit alpha 2 (ITGA2), transcript variant 1, mRNA.
ACCESSION
NM_002203
VERSION
NM_002203.3

This sequence information is just for reference only.

Integrin alpha 2 Family & Reagents

Gene family

Integrin alpha 2 Gene family reagents (CD molecules)

Approved Symbol Reagent list
BST2
CD5
LILRA3
SLAMF7
TNFRSF10D
ENPP3
CD180
CD6
CD86
F11R
Approved Symbol Reagent list
CD93
KIR2DL4
IL1R2
CLEC4M
CD28
IL2RB
CD300C
FCAR
NCR1
IL3Ra

Integrin alpha 2 cDNA / Gene Alias

  • alpha 2 subunit of VLA-2 receptor
  • CD49b

Integrin alpha 2 cDNA / Gene Expression

Broad expression in skin (RPKM 8.4), adrenal (RPKM 7.9) and 21 other tissues