IL36RN/IL-1F5 Protein Overview: Sequence, Structure, Function and Protein Interaction

IL36RN/IL-1F5 Protein Overview

Members of the IL1 (see IL1A; 147760) family, such as IL1F5, are structurally related cytokines and cell surface receptors that mediate inflammation. IL1F5 is part of an IL1 signaling system in epithelia and antagonizes IL1F6 (605509) and IL1F9 (605542) at the IL1R3 (IL1RAP; 602626)/IL1R6 (IL1RL2; 604512) receptor complex (summary by Johnston et al., 2011).

IL36RN/IL-1F5 protein family

Belongs to the IL-1 family.

IL36RN/IL-1F5 protein name

Recommended name
Interleukin-36 receptor antagonist protein
Short name
IL-36Ra||IL-1RP3||IL-1HY1||IL-1 delta||IL-1F5
family of interleukin 1-delta, FIL1, FIL1(DELTA), FIL1D, IL-1 related protein 3, IL-1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, interleukin-1 HY1, interleukin-1 receptor antagonist homolog 1, MGC29840
Alternative name
FIL1 delta IL-1-related protein 3 Interleukin-1 HY1 Interleukin-1 delta Interleukin-1 family member 5 Interleukin-1 receptor antagonist homolog 1 Interleukin-1-like protein 1

IL36RN/IL-1F5 Protein Sequence

Species Human IL36RN/IL-1F5 protein
Length 155
Mass (Da) 16962
Sequence Human IL36RN/IL-1F5 protein sequence
Species Mouse IL36RN/IL-1F5 protein
Length 156
Mass (Da) 17136
Sequence Mouse IL36RN/IL-1F5 protein sequence
Mass (Da)

IL36RN/IL-1F5 Protein Molecular Weight & PI

Interleukin-36 receptor antagonist protein (IL-36Ra) (FIL1 delta) (IL-1-related protein 3) (IL-1RP3) (Interleukin-1 HY1) (IL-1HY1) (Interleukin-1 delta) (IL-1 delta) (Interleukin-1 family member 5) (IL-1F5) (Interleukin-1 receptor antagonist homolog 1) (IL-1ra homolog 1) (Interleukin-1-like protein 1) (IL-1L1) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 2-155 Interleukin-36 receptor antagonist

Molecular weight (Da)


Theoretical pI


IL36RN/IL-1F5 Protein Structure

Crystal Structure of Double Loop-Swapped Interleukin-36Ra With Additional Point Mutations
2014-02-21   Released:  2014-06-25
Deposition Author(s)
Guenther, S., Sundberg, E.J.
Homo sapiens
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
1.5500 Å
R-Value Free
R-Value Work
4P0L From PDB

Human IL36RN/IL-1F5 protein Secondary structure

IL36RN/IL-1F5 Protein Interaction

Recombinant IL36RN/IL-1F5 Protein Feature

IL36RN/IL-1F5 Protein, Human, Recombinant

High Purity
> 99 % as determined by SDS-PAGE
Low Endotoxin
Please contact us for more information.
High Activity
Measured by its ability to inhibit IL36α-induced IL8 secretion in A431 human epithelial carcinoma cells. The ED50 for this effect is typically 0.1-0.4μg/mL in the presence of 20ng/mL IL36α.

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