IL-6R Protein Overview: Sequence, Structure, Function and Protein Interaction

IL-6R Protein Overview

Interleukin-6 (IL6; 147620) is a multifunctional cytokine that is essential to the regulation of the immune response, hematopoiesis, and acute-phase reactions. It exerts its many actions through a heterodimeric receptor consisting of 2 membrane-bound glycoproteins: an 80-kD IL6-binding subunit, IL6R-alpha, and gp130 (IL6ST; 600694), which is responsible for signal transduction and stabilization of the alpha-chain ligand complex. Yamasaki et al. (1988) isolated a cDNA encoding the receptor for interleukin-6. They showed that it codes for a protein consisting of 468 amino acids, including a signal peptide of about 19 amino acids and a domain of about 90 amino acids that is similar to a domain in the immunoglobulin superfamily. The cytoplasmic domain of about 82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors.

IL-6R protein family

Belongs to the type I cytokine receptor family. Type 3 subfamily.

IL-6R protein name

Recommended name
Interleukin-6 receptor subunit alpha
Short name
IL-6 receptor subunit alpha||IL-6R subunit al
Alternative name
IL-6R 1 Membrane glycoprotein 80 CD_antigen: CD126

IL-6R Gene family protein

IL-6R Protein Sequence

Species Human IL-6R protein
Length 468
Mass (Da) 51548
Sequence Human IL-6R protein sequence
Mass (Da)
Species Rat IL-6R protein
Length 462
Mass (Da) 50401
Sequence Rat IL-6R protein sequence

IL-6R Protein Molecular Weight & PI

Interleukin-6 receptor subunit alpha precursor (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 20-468 Interleukin-6 receptor subunit alpha.

Molecular weight (Da)


Theoretical pI


IL-6R Protein Structure

Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies
2016-01-25   Released:  2017-01-25
Deposition Author(s)
Adams, R., Griffin, R., Doyle, C., Ettorre, A.
Homo sapiens
Expression System
Escherichia coli, Homo sapiens
Experimental Data Snapshot
2.7000 Å
R-Value Free
R-Value Work

Human IL-6R protein Secondary structure

IL-6R Protein Interaction

Recombinant IL-6R Protein Feature

IL-6R Protein, Human, Recombinant (ECD, His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
1. Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL-6 at 8 μg/mL (100μl/well) can bind recombinant human IL6R with a linear range of 1.25-20.0 ng/ml. 2. Measured by its ability to enhance the IL6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 20-80 ng/ml. 3. Using the Octet RED System, the affinity constant (Kd) of IL-6R Protein, Human, Recombinant (His Tag) (Cat. 10398-H08H) bound Anti-IL6R Antibody (Cat. 10398-MM08) was 0.1 nM.

Recombinant IL-6R protein citations

Chikusetsusaponin IVa Butyl Ester (CS-IVa-Be), a Novel IL6R Antagonist, Inhibits IL6/STAT3 Signaling Pathway and Induces Cancer Cell Apoptosis
Yang, J;Qian, S;Cai, X;Lu, W;Hu, C;Sun, X;Yang, Y;Yu, Q;Gao, SP;Cao, P;
Mol. Cancer Ther.

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