IL-18 Gene Sequence, Family, Fuction and Expression Information

IL-18 cDNA / Gene Overview

IL18 gene / cDNA is a protein-coding gene which located on 11q23.1. The IL18 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.190 organisms have orthologs with human gene IL18.

IL-18 cDNA / Gene Function

The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

IL-18 cDNA / Gene Sequence

LOCUS
LOCUS NM_001562 1163 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens interleukin 18 (IL18), transcript variant 1, mRNA.
ACCESSION
NM_001562
VERSION
NM_001562.3

This sequence information is just for reference only.

IL-18 Family & Reagents

Gene family

IL-18 Gene family reagents (Interleukins)

Approved Symbol Reagent list
IL25
IL37
IL36G
IL17F
IL31
IL20
IL36B
CXCL8
IL33
IL2
Approved Symbol Reagent list
IL23A
IL11
IL1A
IL17B
IL6
IL36RN
IL24
IL12B
IL1B
IL12A

IL-18 cDNA / Gene Alias

  • IGIF
  • IL-18
  • IL1F4
  • IL-1g
  • interferon-gamma-inducing factor

IL-18 cDNA / Gene Expression

Biased expression in skin (RPKM 65.5), esophagus (RPKM 50.9) and 12 other tissues

Recombinant IL-18 protein citations

Title
Electroacupuncture ameliorates cardiopulmonary bypass induced apoptosis in lung via ROS/Nrf2/NLRP3 inflammasome pathway
Year
2019
Author
Dhar, R;Zhang, L;Li, Y;Rana, MN;Hu, Z;Li, Z;Cui, H;Tang, H;
Journal
Life Sci.