IFN-omega Protein Overview: Sequence, Structure, Function and Protein Interaction

IFN-omega Protein Overview

Henco et al. (1985) compiled partial maps of the interferon gene cluster located on 9p21. These maps showed that members of the 2 main families of genes in the IFN superfamily, interferon-alpha (147660) and interferon-omega (IFNW), are interspersed. Olopade et al. (1992) studied the deletions of the short arm of chromosome 9 frequently observed in acute lymphoblastic leukemia and in gliomas. These deletions often include the entire interferon gene cluster, which comprises about 26 IFNA, IFNW, and IFNB1 (147640) genes, as well as the gene for methylthioadenosine phosphorylase (MTAP; 156540). By comparing microscopic deletions with the genes lost at the molecular level, Olopade et al. (1992) determined the order of these genes on 9p to be tel--IFNB1--IFNA/IFNW cluster--MTAP--cen. In a few cell lines and in primary leukemia cells, they observed deletions that had breakpoints within the IFN gene cluster and resulted in partial loss of the IFN genes. These partial deletions allowed them to determine the order of some genes or groups of genes in the IFNA/IFNW gene cluster. From their deletion analysis, Olopade et al. (1992) deduced the following order of the IFN gene on 9p: pter--IFNB1--(IFNW1, IFNA21)--IFNWP15--IFNA4--IFNW9--IFNA7--IFNA10--IFNWP18--IFNAP16--IFNA17--IFNA14--(IFNA22, IFNA5, IFNAP20, IFNA6, IFNA13, IFNA2)--(IFNA8, IFNW2, IFNWP19, IFNA1)--MTAP--cen. The genes within the large linkage group are arranged in tandem with their 3-prime end pointing toward the telomere of the short arm. Thus, at least 2 functional interferon-omega genes, IFNW1 and IFNW2, were mapped and several IFNW pseudogenes, e.g., IFNWP15, were localized. PseudogenesDiaz and Bohlander (1993) provided a tabulation of the nomenclature of the human interferon genes and listed IFNWP2 as a pseudogene. The only functional interferon-omega gene is presumably IFNW1.

IFN-omega protein family

Belongs to the alpha/beta interferon family.

IFN-omega protein name

Recommended name
Interferon omega-1
IFN-omega 1, interferon omega-1
Alternative name
Interferon alpha-II-1

IFN-omega Protein Sequence

Species Human IFN-omega protein
Length 195
Mass (Da) 22319
Sequence Human IFN-omega protein sequence
Mass (Da)
Mass (Da)

IFN-omega Protein Molecular Weight & PI

Interferon omega-1 precursor (Interferon alpha-II-1) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 22-195 Interferon omega-1.

Molecular weight (Da)


Theoretical pI


IFN-omega Protein Structure

human IFNw-IFNAR ternary complex
2011-06-10   Released:  2011-08-31
Deposition Author(s)
Thomas, C., Garcia, K.C.
Homo sapiens
Expression System
Homo sapiens, Trichoplusia ni
Experimental Data Snapshot
3.5000 Å
R-Value Free
R-Value Work
3SE4 From PDB

IFN-omega Protein Interaction

Recombinant IFN-omega Protein Feature

IFN-omega Protein, Human, Recombinant (His Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV). The ED50 for this effect is typically 2-8 pg/mL.

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