ICOS ligand Information: ICOS ligand Protein, ICOS ligand Antibody and ICOS ligand Gene

ICOS ligand Gene family

ICOS ligand Protein

ICOS ligand protein function

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). {ECO:0000250}.

ICOS ligand protein expression

Tissue specificity

Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.

Induction

Constitutive expression is further enhanced by treatment with TNF in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells.

ICOS ligand protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    302.00
  • Mass (Da)
    33.00

ICOS ligand Antibody

There are 13 ICOS ligand antibodies which are validated in multiple tissues with various applications, including FCM, ELISA(Cap), ELISA, ELISA(Det), IHC-P. There are 5 ICOS ligand antibody for FCM, 1 ICOS ligand antibody for ELISA(Cap), 6 ICOS ligand antibody for ELISA, 1 ICOS ligand antibody for ELISA(Det), 1 ICOS ligand antibody for IHC-P. Among all these ICOS ligand antibodies, there are 6 anti-ICOS ligand mouse monoclonal antibodies , 1 anti-ICOS ligand rabbit monoclonal antibodies , 6 anti-ICOS ligand rabbit polyclonal antibodies . All the ICOS ligand anbodies are produced in house and all are in stock. ICOS ligand antibody customerized service is available.

ICOS ligand Gene

ICOSLG gene / cDNA is a protein-coding gene which located on 21q22.3. The ICOSLG gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.156 organisms have orthologs with human gene ICOSLG.