HGF Gene Sequence, Family, Fuction and Expression Information
HGF cDNA / Gene Overview
HGF gene / cDNA is a protein-coding gene which located on 7q21.11. The HGF gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.217 organisms have orthologs with human gene HGF.
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
HGF cDNA / Gene Sequence
LOCUS NM_000601 6002 bp mRNA linear PRI 29-JUL-2018
Homo sapiens hepatocyte growth factor (HGF), transcript variant 1, mRNA.
This sequence information is just for reference only.
The role of IL-6 trans-signaling in liver regeneration after partial hepatectomy Dissertation
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