HGF Gene Sequence, Family, Fuction and Expression Information

HGF cDNA / Gene Overview

HGF gene / cDNA is a protein-coding gene which located on 7q21.11. The HGF gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.217 organisms have orthologs with human gene HGF.

HGF cDNA / Gene Function

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

HGF cDNA / Gene Sequence

LOCUS
LOCUS NM_000601 6002 bp mRNA linear PRI 29-JUL-2018
DEFINITION
Homo sapiens hepatocyte growth factor (HGF), transcript variant 1, mRNA.
ACCESSION
NM_000601
VERSION
NM_000601.5

This sequence information is just for reference only.

HGF Family & Reagents

HGF Gene family reagents (Deafness associated genes)

Approved Symbol Reagent list
CD164
COCH
KITLG
MSRB3
USH1C
Approved Symbol Reagent list
CIB2
DIABLO
MET
SerpinB6
   

HGF cDNA / Gene Alias

  • fibroblast-derived tumor cytotoxic factor
  • F-TCF
  • hepatopoietin A
  • HGFB
  • HPTA
  • lung fibroblast-derived mitogen
  • scatter factor
  • SF

HGF cDNA / Gene Expression

Biased expression in placenta (RPKM 90.6), adrenal (RPKM 7.0) and 2 other tissues

Recombinant HGF protein citations

Title
Analysis of soluble factors in conditioned media derived from primary cultures of cirrhotic liver of biliary atresia
Year
2017
Author
Yamazaki, T;Wakai, M;Enosawa, S;Tokiwa, T;
Journal
In Vitro Cell. Dev. Biol. Anim
Title
Impaired integrin α5 /β1 -mediated hepatocyte growth factor release by stellate cells of the aged liver
Year
2020
Author
Rohn, F;Kordes, C;Buschmann, T;Reichert, D;Wammers, M;Poschmann, G;Stühler, K;Benk, AS;Geiger, F;Spatz, JP;Häussinger, D;
Journal
Aging Cell
Title
The role of IL-6 trans-signaling in liver regeneration after partial hepatectomy Dissertation
Year
2020
Author
Modares, NF;
Journal
Thesis