GDNF Information: GDNF Protein, GDNF Antibody and GDNF Gene

GDNF Gene family

GDNF Protein

GDNF protein function

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. {ECO:0000269|PubMed:8493557}.

GDNF protein expression

Tissue specificity

In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change.

Induction

By cAMP, 12-O-tetradecanoylphorbol-13-acetate (TPA) and FGF2.

GDNF protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    211.00
  • Mass (Da)
    23.00

GDNF Antibody

There are 2 GDNF antibodies which are validated in multiple tissues with various applications, including ICC/IF, ELISA. There are 1 GDNF antibody for ICC/IF, 1 GDNF antibody for ELISA. Among all these GDNF antibodies, there are 2 anti-GDNF rabbit polyclonal antibodies . All the GDNF anbodies are produced in house and all are in stock. GDNF antibody customerized service is available.

GDNF Gene

GDNF gene / cDNA is a protein-coding gene which located on 5p13.2. The GDNF gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.237 organisms have orthologs with human gene GDNF.