FGF2 Protein Overview: Sequence, Structure, Function and Protein Interaction

FGF2 Protein Overview

Fibroblast growth factor-2 (FGF2) is a wide-spectrum mitogenic, angiogenic, and neurotrophic factor that is expressed at low levels in many tissues and cell types and reaches high concentrations in brain and pituitary. FGF2 has been implicated in a multitude of physiologic and pathologic processes, including limb development, angiogenesis, wound healing, and tumor growth (summary by Ortega et al., 1998).

FGF2 protein family

Belongs to the heparin-binding growth factors family.

FGF2 protein name

Recommended name
Fibroblast growth factor 2
Short name
FGF-2||bFGF||HBGF-2
Alternative name
Basic fibroblast growth factor Heparin-binding growth factor 2

FGF2 Protein Sequence

Species Human FGF2 protein
Length 288
Mass (Da) 30770
Sequence Human FGF2 protein sequence
Species Mouse FGF2 protein
Length 154
Mass (Da) 17153
Sequence Mouse FGF2 protein sequence
Species Rat FGF2 protein
Length 154
Mass (Da) 17139
Sequence Rat FGF2 protein sequence

FGF2 Protein Molecular Weight & PI

Fibroblast growth factor 2 precursor (FGF-2) (Basic fibroblast growth factor) (bFGF) (Heparin-binding growth factor 2) (HBGF-2) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 143-288 Fibroblast growth factor 2.

Molecular weight (Da)

16407.81

Theoretical pI

9.59

FGF2 Protein Structure

CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
Deposited
2000-04-19   Released:  2000-05-31
Deposition Author(s)
Plotnikov, A.N., Hubbard, S.R., Schlessinger, J., Mohammadi, M.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.2000 Å
R-Value Free
0.273
R-Value Work
0.248
1EV2 From PDB

Human FGF2 protein Secondary structure

FGF2 Protein Interaction

Recombinant FGF2 Protein Feature

FGF2 Protein, Human, Recombinant

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg protein as determined by the LAL method
High Activity
Measured in a cell proliferation assay using BALB/c 3T3 mouse embryonic fibroblasts. The ED50 for this effect is typically 0.02-0.1 ng/ml.

Recombinant FGF2 protein citations

Title
Potent retro-inverso D-peptide for simultaneous targeting of angiogenic blood vasculature and tumor cells
Year
2013
Author
Li, Y;Lei, Y;Wagner, E;Xie, C;Lu, W;Zhu, J;Shen, J;Wang, J;Liu, M;
Journal
Bioconjug. Chem.
Title
Establishment of a Rabbit Oct4 Promoter-Based EGFP Reporter System
Year
2014
Author
Quan, L;Chen, Y;Song, J;Yan, Q;Zhang, Q;Lai, S;Fan, N;Xin, J;Zou, Q;Lai, L;
Journal
PLoS ONE
Title
Slow and sustained nitric oxide releasing compounds inhibit multipotent vascular stem cell proliferation and differentiation without causing cell death
Year
2014
Author
Curtis, BM;Leix, KA;Ji, Y;Glaves, RS;Ash, DE;Mohanty, DK;
Journal
Biochem. Biophys. Res. Commun.
Title
A lab-centred approach for initiating early stage regeneration of dental pulp using specialised alginate biomimetic microenvironments
Year
2015
Author
Bhoj, M;
Journal
HKU Theses Online (HKUTO)
Title
Expression of functional recombinant human fibroblast growth factor 8b and its protective effects on MPP(+)-lesioned PC12 cells
Year
2015
Author
Chen, N;Ma, J;Zhao, Y;Wu, M;Yang, H;Gong, W;Chao, J;Li, X;
Journal
Appl. Microbiol. Biotechnol.
Title
Lífvirkni í rót rabarbara
Year
2016
Author
Arnardóttir, S;
Journal
Thesis
Title
Receptor FGFRL1 does not promote cell proliferation but induces cell adhesion
Year
2016
Author
Yang, X;Steinberg, F;Zhuang, L;Bessey, R;Trueb, B;
Journal
Int. J. Mol. Med.
Title
Cancer stem-like cell related protein CD166 degrades through E3 ubiquitin ligase CHIP in head and neck cancer
Year
2017
Author
Xiao, M;Yan, M;Zhang, J;Xu, Q;Qi, S;Wang, X;Chen, W;
Journal
Exp. Cell Res
Title
Optimizing mesoderm progenitor selection and three-dimensional microniche culture allows highly efficient endothelial differentiation and ischemic tissue repair from human pluripotent stem cells
Year
2017
Author
Zhang, F;Wang, L;Li, Y;Liu, W;Duan, F;Huang, R;Chen, X;Chang, SC;Du, Y;Na, J;
Journal
Stem Cell Res Ther
Title
PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs
Year
2017
Author
Shan, Y;Liang, Z;Xing, Q;Zhang, T;Wang, B;Tian, S;Huang, W;Zhang, Y;Yao, J;Zhu, Y;Huang, K;Liu, Y;Wang, X;Chen, Q;Zhang, J;Shang, B;Li, S;Shi, X;Liao, B;Zhang, C;Lai, K;Zhong, X;Shu, X;Wang, J;Yao, H;Chen, J;Pei, D;Pan, G;
Journal
Nat Commun
Title
A fusion antitumor peptide regulates proliferation and apoptosis of endothelial cells
Year
2018
Author
Xu, Y;Qiang, X;Xing, L;Wang, H;Zhang, J;Zhang, F;Caliskan, B;Wang, M;Qiu, Z;
Journal
Amino Acids
Title
A two-step process for capture and purification of human basic fibroblast growth factor from E. coli homogenate: Yield versus endotoxin clearance
Year
2018
Author
Sauer, DG;Mosor, M;Frank, AC;Weiß, F;Christler, A;Walch, N;Jungbauer, A;Dürauer, A;
Journal
Protein Expr. Purif.
Title
Androgen Promotes Differentiation of PLZF+ Spermatogonia pool via Indirect Regulatory Pattern
Year
2018
Author
Wang, J;Li, J;Gu, Y;Xia, Q;Song, W;Zhang, X;Yang, Y;Wang, W;Li, H;Zou, K;
Journal
bioRxiv
Title
Exostosin-like 2 regulates FGF2 signaling by controlling the endocytosis of FGF2
Year
2018
Author
Nadanaka, S;Kitagawa, H;
Journal
Biochim. Biophys. Acta
Title
In Vitro Modeling of Human Germ Cell Development Using Pluripotent Stem Cells
Year
2018
Author
Zhao, Y;Ye, S;Liang, D;Wang, P;Fu, J;Ma, Q;Kong, R;Shi, L;Gong, X;Chen, W;Ding, W;Yang, W;Zhu, Z;Chen, H;Sun, X;Zhu, J;Li, Z;Wang, Y;
Journal
Stem Cell Reports
Title
LincU Preserves Naïve Pluripotency by Restricting ERK Activity in Embryonic Stem Cells
Year
2018
Author
Jiapaer, Z;Li, G;Ye, D;Bai, M;Li, J;Guo, X;Du, Y;Su, D;Jia, W;Chen, W;Wang, G;Yu, Y;Zhu, F;Wan, X;Kang, J;
Journal
Stem Cell Reports
Title
Sulfated polysaccharide mediated TGF-β1 presentation in pre-formed injectable scaffolds for cartilage tissue engineering
Year
2018
Author
Waghmare, N;Arora, A;Bhattacharjee, A;Katti, D;
Journal
Carbohydrate Polymers
Title
Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination
Year
2019
Author
Liu, Z;Yan, M;Liang, Y;Liu, M;Zhang, K;Shao, D;Jiang, R;Li, L;Wang, C;Nussenzveig, DR;Zhang, K;Chen, S;Zhong, C;Mo, W;Fontoura, BMA;Zhang, L;
Journal
Neuron
Title
A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism
Year
2019
Author
Ou, Z;Ma, Y;Sun, Y;Zheng, G;Wang, S;Xing, R;Chen, X;Han, Y;Wang, J;Lu, QR;Zhao, TJ;Chen, Y;
Journal
Cell Rep
Title
Characterization of porcine extraembryonic endoderm cells
Year
2019
Author
Shen, QY;Yu, S;Zhang, Y;Zhou, Z;Zhu, ZS;Pan, Q;Lv, S;Niu, HM;Li, N;Peng, S;Liao, MZ;Wang, HY;Lei, AM;Miao, YL;Liu, ZH;Hua, JL;
Journal
Cell Prolif.
Title
ColXV Aggravates Adipocyte Apoptosis by Facilitating Abnormal Extracellular Matrix Remodeling in Mice
Year
2020
Author
Xia, T;Shen, Z;Cai, J;Pan, M;Sun, C;
Journal
Int J Mol Sci

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