FGF2 Gene Sequence, Family, Fuction and Expression Information
FGF2 cDNA / Gene Overview
FGF2 gene / cDNA is a protein-coding gene which located on 4q28.1. The FGF2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.207 organisms have orthologs with human gene FGF2.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
FGF2 cDNA / Gene Sequence
LOCUS NM_002006 6781 bp mRNA linear PRI 28-JUL-2018
Homo sapiens fibroblast growth factor 2 (FGF2), mRNA.
This sequence information is just for reference only.
Broad expression in fat (RPKM 17.2), endometrium (RPKM 8.8) and 21 other tissues
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