FGF2 Gene Sequence, Family, Fuction and Expression Information

FGF2 cDNA / Gene Overview

FGF2 gene / cDNA is a protein-coding gene which located on 4q28.1. The FGF2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.207 organisms have orthologs with human gene FGF2.

FGF2 cDNA / Gene Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]

FGF2 cDNA / Gene Sequence

LOCUS
LOCUS NM_002006 6781 bp mRNA linear PRI 28-JUL-2018
DEFINITION
Homo sapiens fibroblast growth factor 2 (FGF2), mRNA.
ACCESSION
NM_002006
VERSION
NM_002006.5

This sequence information is just for reference only.

FGF2 Family & Reagents

Gene family

FGF2 Gene family reagents (Endogenous ligands)

Approved Symbol Reagent list
CXCL2
IL1B
CD274
EPO
BMP4
CCL16
BMP5
CCL28
APP
KNG1
Approved Symbol Reagent list
AMH
CXCL3
RARRES2
CXCL9
LGALS1
FGF9
PTN
ADIPOQ
IL1A
PPBP

FGF2 cDNA / Gene Expression

Broad expression in fat (RPKM 17.2), endometrium (RPKM 8.8) and 21 other tissues