EphB2 Gene Sequence, Family, Fuction and Expression Information

EphB2 cDNA / Gene Overview

EphB2 gene / cDNA is a protein-coding gene which located on 1p36.12. The EPHB2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and zebrafish.189 organisms have orthologs with human gene EPHB2.

EphB2 cDNA / Gene Function

This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

EphB2 cDNA / Gene Sequence

LOCUS
LOCUS NM_017449 11054 bp mRNA linear PRI 01-JUL-2018
DEFINITION
Homo sapiens EPH receptor B2 (EPHB2), transcript variant 1, mRNA.
ACCESSION
NM_017449
VERSION
NM_017449.4

This sequence information is just for reference only.

EphB2 Family & Reagents

EphB2 Gene family reagents (Fibronectin type III domain containing)

Approved Symbol Reagent list
IFNGR2
NCAM2
NCAM1
CNTN3
FLRT3
AXL
CHL1
EphB4
IL12RB1
TEK
Approved Symbol Reagent list
OSMR
EphA2
FN1
INSR
CNTN2
FLRT2
FLRT1
EPHA1
PTPRJ
EphA4

EphB2 Gene family reagents (Sterile alpha motif domain containing)

Approved Symbol Reagent list
CNKSR3
EphA2
EphA4
EphA7
EphB1
EphB4
STIM1
Approved Symbol Reagent list
EPHA1
EphA3
EphA6
EPHA8
EphB3
EphB6
   

EphB2 Gene family reagents (EPH receptors)

Approved Symbol Reagent list
EPHA1
EphA3
EphA6
EPHA8
EphB3
EphB6
Approved Symbol Reagent list
EphA2
EphA4
EphA7
EphB1
EphB4
   

EphB2 cDNA / Gene Alias

  • Hek5
  • Tyro5

EphB2 cDNA / Gene Expression

Broad expression in colon (RPKM 7.3), small intestine (RPKM 5.2) and 17 other tissues