DR5/TRAIL R2 Gene Sequence, Family, Fuction and Expression Information
DR5/TRAIL R2 cDNA / Gene Overview
TNFRSF10B gene / cDNA is a protein-coding gene which located on 8p21.3. The TNFRSF10B gene is conserved in chimpanzee, Rhesus monkey, chicken, and frog.48 organisms have orthologs with human gene TNFRSF10B.
DR5/TRAIL R2 cDNA / Gene Function
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
DR5/TRAIL R2 cDNA / Gene Sequence
LOCUS
LOCUS NM_147187 4067 bp mRNA linear PRI 15-JUL-2018
DEFINITION
Homo sapiens TNF receptor superfamily member 10b (TNFRSF10B), transcript variant 2, mRNA.
ACCESSION
NM_147187
VERSION
NM_147187.2
This sequence information is just for reference only.
DR5/TRAIL R2 Family & Reagents
DR5/TRAIL R2 Gene family reagents (CD molecules)
DR5/TRAIL R2 Gene family reagents (Tumor necrosis factor receptor superfamily)
DR5/TRAIL R2 cDNA / Gene Alias
- CD262
- DR5
- KILLER
- TRAILR2
- TRAIL-R2
- TRICK2A
- TRICKB
DR5/TRAIL R2 cDNA / Gene Expression
Ubiquitous expression in gall bladder (RPKM 17.8), urinary bladder (RPKM 14.8) and 25 other tissues
Recombinant DR5/TRAIL R2 protein citations
Title
A Novel Fully Human Agonistic Single Chain Fragment Variable Antibody Targeting Death Receptor 5 with Potent Antitumor Activity In Vitro and In Vivo
Year
2017
Author
Lei, G;Xu, M;Xu, Z;Gu, L;Lu, C;Bai, Z;Wang, Y;Zhang, Y;Hu, H;Jiang, Y;Zhao, W;Tan, S;
Journal
Int J Mol Sci
