Types of Growth Factors

Classes of Growth Factors & Receptors

Numerous growth factors have been isolated, and they are classified into different families on the basis of their target cells, functions, structures and molecular evolution. Some well-known families are demonstrated as follows:

Fibroblast growth factor family

Vascular endothelial growth factor family

Insulin-like growth factor family

Epidermal growth factor family

Platelet-derived growth factor

Nerve growth factor family

Hepatocyte growth factor family

Hepatoma-derived growth factor family

Connective tissue growth factor family

Transforming Growth Factor α (TGFα) family

Transforming Growth Factor β (TGFβ) family


Pardali E, et al. (2009) Transforming growth factor-beta signaling and tumor angiogenesis. Front Biosci. 14:4848-61.
Fiore M, et al. (2009) Nerve growth factor as a signaling molecule for nerve cells and also for the neuroendocrine-immune systems. Rev Neurosci. 20(2):133-45.
Li G, et al. (2010) The epidermal growth factor variant III peptide vaccine for treatment of malignant gliomas. Neurosurg Clin N Am. 21(1):87-93.