Clusterin Information: Clusterin Protein, Clusterin Antibody and Clusterin Gene

Clusterin Protein

Clusterin protein function

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:12047389, ECO:0000269|PubMed:12176985, ECO:0000269|PubMed:12551933, ECO:0000269|PubMed:12882985, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17407782, ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17689225, ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:19535339, ECO:0000269|PubMed:19996109, ECO:0000269|PubMed:20068069, ECO:0000269|PubMed:21505792}.

Clusterin protein expression

Tissue specificity

Detected in blood plasma, cerebrospinal fluid, milk, seminal plasma and colon mucosa. Detected in the germinal center of colon lymphoid nodules and in colon parasympathetic ganglia of the Auerbach plexus (at protein level). Ubiquitous. Detected in brain, testis, ovary, liver and pancreas, and at lower levels in kidney, heart, spleen and lung.

Induction

Up-regulated in response to enterovirus 71 (EV71) infection (at protein level). Up-regulated by agents that induce apoptosis, both at mRNA and protein level. Isoform 1 is up-regulated by androgen. Isoform 2 is down-regulated by androgen.

Clusterin protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    449.00
  • Mass (Da)
    52.00

Clusterin Antibody

There are 15 Clusterin antibodies which are validated in multiple tissues with various applications, including WB, ELISA, FCM, ICC/IF, IHC-P, IP. There are 2 Clusterin antibody for WB, 8 Clusterin antibody for ELISA, 5 Clusterin antibody for FCM, 3 Clusterin antibody for ICC/IF, 1 Clusterin antibody for IHC-P, 1 Clusterin antibody for IP. Among all these Clusterin antibodies, there are 3 anti-Clusterin mouse monoclonal antibodies , 5 anti-Clusterin rabbit monoclonal antibodies , 7 anti-Clusterin rabbit polyclonal antibodies . All the Clusterin anbodies are produced in house and all are in stock. Clusterin antibody customerized service is available.

Clusterin Gene

CLU gene / cDNA is a protein-coding gene which located on 8p21.1. The CLU gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.196 organisms have orthologs with human gene CLU.