CD98 Protein Overview: Sequence, Structure, Function and Protein Interaction

CD98 Protein Overview

CD98 protein family

Belongs to the SLC3A transporter family.

CD98 protein name

Recommended name
4F2 cell-surface antigen heavy chain
Short name
4F2, 4F2 cell-surface antigen heavy chain, 4F2 heavy chain, 4F2HC, 4T2HC, antigen defined by monoclonal antibody 4F2, antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43, CD98, CD98 heavy chain, CD98HC, heavy chain, lymphocyte activation antigen 4F2 large subunit, monoclonal antibody 44D7, NACAE
Alternative name
4F2 heavy chain antigen Lymphocyte activation antigen 4F2 large subunit Solute carrier family 3 member 2 CD_antigen: CD98

CD98 Gene family protein

Solute carriers

CD98 Protein Sequence

Species Human CD98 protein
Length 630
Mass (Da) 67994
Sequence Human CD98 protein sequence
Species Mouse CD98 protein
Length 526
Mass (Da) 58337
Sequence Mouse CD98 protein sequence
Species Rat CD98 protein
Length 527
Mass (Da) 58072
Sequence Rat CD98 protein sequence

CD98 Protein Molecular Weight & PI

4F2 cell-surface antigen heavy chain (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD98 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-630 4F2 cell-surface antigen heavy chain.

Molecular weight (Da)


Theoretical pI


CD98 Protein Structure

Crystal Structure of human ED-4F2hc
2006-03-21   Released:  2007-03-27
Deposition Author(s)
Fort, J., Fita, I., Palacin, M.
Homo sapiens
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
2.8000 Å
R-Value Free
R-Value Work
2DH3 From PDB

Human CD98 protein Secondary structure

CD98 Protein Interaction

Recombinant CD98 Protein Feature

CD98 Protein, Human, Recombinant (His Tag)

High Purity
> 97 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant CD98 protein citations

Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice
Xiao, B;Laroui, H;Viennois, E;Ayyadurai, S;Charania, MA;Zhang, Y;Zhang, Z;Baker, MT;Zhang, B;Gewirtz, AT;Merlin, D;

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