CD30/TNFRSF8 Protein Overview: Sequence, Structure, Function and Protein Interaction
CD30/TNFRSF8 Protein Overview
CD30/TNFRSF8 protein name
Recommended name
Tumor necrosis factor receptor superfamily member 8
Aliases
KI-1
Alternative name
CD30L receptor
Ki-1 antigen
Lymphocyte activation antigen CD30
CD_antigen: CD30
CD30/TNFRSF8 Gene family protein
CD molecules
| Approved symbol | Common name |
|---|---|
| IL2RB | CD122/IL2RB protein, recombinant |
| PLAUR | uPAR/PLAUR protein, recombinant |
| NECTIN1 | PVRL1/NECTIN1 protein, recombinant |
| CD84 | CD84 protein, recombinant |
| TNFRSF1B | TNFR2/TNFRSF1B protein, recombinant |
| CD58 | CD58 protein, recombinant |
| SLAMF6 | SLAMF6 protein, recombinant |
| MCAM | CD146/MCAM protein, recombinant |
| CD48 | CD48 protein, recombinant |
| SELE | E-Selectin protein, recombinant |
| TNFRSF10C | DcR1/TRAILR3 protein, recombinant |
| CD1B | CD1B protein, recombinant |
| KLRK1 | NKG2D protein, recombinant |
| PTPRJ | DEP-1 protein, recombinant |
| MME | CD10 protein, recombinant |
| PSG1 | PSG1 protein, recombinant |
| CLEC4D | CLEC4D protein, recombinant |
| CD276 | B7-H3 protein, recombinant |
| IL13Ra1 | IL13RA1 protein, recombinant |
| CD207 | Langerin/CD207 protein, recombinant |
Tumor necrosis factor receptor superfamily
| Approved symbol | Common name |
|---|---|
| TNFRSF1B | TNFR2/TNFRSF1B protein, recombinant |
| TNFRSF6B | DcR3 protein, recombinant |
| TNFRSF14 | HVEM protein, recombinant |
| LTBR | LTBR protein, recombinant |
| TNFRSF13B | TACI protein, recombinant |
| TNFRSF10A | DR4/TRAIL R1 protein, recombinant |
| TNFRSF21 | DR6 protein, recombinant |
| TNFRSF17 | BCMA protein, recombinant |
| TNFRSF10C | DcR1/TRAILR3 protein, recombinant |
| TNFRSF11A | RANK/TNFRSF11A protein, recombinant |
| CD40 | CD40 protein, recombinant |
| TNFRSF9 | CD137 protein, recombinant |
| TNFRSF18 | GITR protein, recombinant |
| FAS | Fas/CD95 protein, recombinant |
| TNFRSF12A | TWEAKR protein, recombinant |
| EDA2R | EDA2R protein, recombinant |
| TNFRSF10D | DcR2/TRAIL R4 protein, recombinant |
| TNFRSF11B | Osteoprotegerin protein, recombinant |
| TNFRSF25 | DR3 protein, recombinant |
| RELT | RELT/TNFRSF19L protein, recombinant |
CD30/TNFRSF8 Protein Sequence
| Species | Human CD30/TNFRSF8 protein |
|---|---|
| Length | 595 |
| Mass (Da) | 63747 |
| Sequence | Human CD30/TNFRSF8 protein sequence |
| Species | Mouse CD30/TNFRSF8 protein |
|---|---|
| Length | 498 |
| Mass (Da) | 53216 |
| Sequence | Mouse CD30/TNFRSF8 protein sequence |
| Species | Rat CD30/TNFRSF8 protein |
|---|---|
| Length | 493 |
| Mass (Da) | 52658 |
| Sequence | Rat CD30/TNFRSF8 protein sequence |
CD30/TNFRSF8 Protein Molecular Weight & PI
Tumor necrosis factor receptor superfamily member 8 precursor (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD30 antigen) Homo sapiens (Human).
The parameters have been computed for the following feature
FT CHAIN 19-595 Tumor necrosis factor receptor
Molecular weight (Da)
61866.81
Theoretical pI
5.32
CD30/TNFRSF8 Protein Structure
STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A HUMAN CD30 PEPTIDE
Deposited
1999-09-07 Released: 2003-12-02
Deposition Author(s)
Ye, H., Park, Y.C., Kreishman, M., Kieff, E., Wu, H.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.0000 Å
R-Value Free
0.244
R-Value Work
0.220
1D01 From PDB
CD30/TNFRSF8 Protein Interaction
Recombinant CD30/TNFRSF8 Protein Feature
CD30/TNFRSF8 Protein, Human, Recombinant (His Tag)
High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
1. Measured by its binding ability in a functional ELISA.
2. Immobilized recombinant human CD30 at 2 μg/ml (100 μl/well) can bind human CD30L Fc Chimera with a linear range of 6.4-800 ng/ml.
Recombinant CD30/TNFRSF8 protein citations
Title
Highly potent, anthracycline-based antibody drug conjugates generated by enzymatic, site-specific conjugation
Year
2017
Author
Stefan, N;Gébleux, R;Waldmeier, L;Hell, T;Escher, M;Wolter, FI;Grawunder, U;Beerli, RR;
Journal
Mol. Cancer Ther
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