CD155/PVR Information: CD155/PVR Protein, CD155/PVR Antibody and CD155/PVR Gene

CD155/PVR Gene family

CD155/PVR Protein

CD155/PVR protein function

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. {ECO:0000269|PubMed:15471548, ECO:0000269|PubMed:15607800}.; (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. {ECO:0000269|PubMed:2538245}.; (Microbial infection) Acts as a receptor for Pseudorabies virus. {ECO:0000269|PubMed:9616127}.; (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells. {ECO:0000269|PubMed:15640804}.

CD155/PVR protein expression

Induction

Transcriptionally regulated by SHH.

CD155/PVR protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    417.00
  • Mass (Da)
    45.00

CD155/PVR Antibody

There are 24 CD155/PVR antibodies which are validated in multiple tissues with various applications, including FCM, ICC/IF, WB, ELISA, IP. There are 9 CD155/PVR antibody for FCM, 2 CD155/PVR antibody for ICC/IF, 5 CD155/PVR antibody for WB, 15 CD155/PVR antibody for ELISA, 2 CD155/PVR antibody for IP. Among all these CD155/PVR antibodies, there are 7 anti-CD155/PVR mouse monoclonal antibodies , 9 anti-CD155/PVR rabbit monoclonal antibodies , 8 anti-CD155/PVR rabbit polyclonal antibodies . All the CD155/PVR anbodies are produced in house and all are in stock. CD155/PVR antibody customerized service is available.

CD155/PVR Gene

PVR gene / cDNA is a protein-coding gene which located on 19q13.31. The PVR gene is conserved in chimpanzee, Rhesus monkey, dog, and cow.69 organisms have orthologs with human gene PVR.