CD122/IL2RB Protein Overview: Sequence, Structure, Function and Protein Interaction

CD122/IL2RB Protein Overview

Tsudo et al. (1989) characterized the interleukin-2 receptor beta chain using 3 monoclonal antibodies, designated Mik-beta1, -beta2, and -beta3. They showed by immunoprecipitation that the beta chain has a molecular mass of 68,000-72,000 Da. Moreover, they found that the beta chain was expressed on the surface of peripheral blood Leu-19+ natural killer cells in the absence of alpha-chain expression. Also see IL2RA (147730). Gnarra et al. (1990) characterized the IL2RB gene. They found that the IL2 receptor is present in 3 forms with respect to binding ability to IL2 (147680): high, intermediate, and low affinity forms. The alpha chain constitutes the low affinity form and is not functional in IL2 internalization and signal transduction. The beta chain by itself constitutes the intermediate affinity form. Hatakeyama et al. (1989) presented evidence that coexpression of the IL2RA and IL2RB genes results in the high affinity form of the receptor.

CD122/IL2RB protein family

Belongs to the type I cytokine receptor family. Type 4 subfamily.

CD122/IL2RB protein name

Recommended name
Interleukin-2 receptor subunit beta
Short name
IL-2 receptor subunit beta||IL-2R subunit bet
Alternative name
High affinity IL-2 receptor subunit beta Interleukin-15 receptor subunit beta p70-75 CD_antigen: CD122

CD122/IL2RB Gene family protein

CD122/IL2RB Protein Sequence

Species Human CD122/IL2RB protein
Length 551
Mass (Da) 61117
Sequence Human CD122/IL2RB protein sequence
Species Mouse CD122/IL2RB protein
Length 539
Mass (Da) 60539
Sequence Mouse CD122/IL2RB protein sequence
Species Rat CD122/IL2RB protein
Length 537
Mass (Da) 60657
Sequence Rat CD122/IL2RB protein sequence

CD122/IL2RB Protein Molecular Weight & PI

Interleukin-2 receptor subunit beta precursor (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD122 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 27-551 Interleukin-2 receptor subunit beta.

Molecular weight (Da)


Theoretical pI


CD122/IL2RB Protein Structure

Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2
2005-10-25   Released:  2006-02-21
Deposition Author(s)
Debler, E.W., Stauber, D.J., Wilson, I.A.
Homo sapiens
Expression System
Trichoplusia ni
Experimental Data Snapshot
3.0000 Å
R-Value Free
R-Value Work

Human CD122/IL2RB protein Secondary structure

CD122/IL2RB Protein Interaction

Recombinant CD122/IL2RB Protein Feature

CD122/IL2RB Protein, Human, Recombinant

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its ability to inhibit IL15-dependent proliferation of MO7e human megakaryocytic leukemic cells in the presence of 4.0 ng/mL of recombinant human IL-15. The ED50 for this effect is 1-4μg/mL.

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