C5a Protein Overview: Sequence, Structure, Function and Protein Interaction

C5a Protein Overview

Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines (Ghiselli and Agrawal, 2005).

C5a protein name

Recommended name
Complement C5
Aliases
C5a, C5a anaphylatoxin, C5b, CPAMD4, prepro-C5
Alternative name
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 Complement C5 beta chain Complement C5 alpha chain C5a anaphylatoxin Complement C5 alpha' chain
From Uniport

C5a Protein Sequence

Species Human C5a protein
Length 1676
Mass (Da) 188305
Sequence Human C5a protein sequence
Species Mouse C5a protein
Length 1680
Mass (Da) 188878
Sequence Mouse C5a protein sequence
Species Rat C5a protein
Length 77
Mass (Da) 8981
Sequence Rat C5a protein sequence

C5a Protein Molecular Weight & PI

Complement C5 precursor (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Contains: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain] Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 678-751 C5a anaphylatoxin.

Molecular weight (Da)

8273.63

Theoretical pI

8.93

C5a Protein Structure

Crystal structure of the human C5aR antagonist C5a-A8
Deposited
2014-03-06   Released:  2014-06-11
Deposition Author(s)
Yatime, L., Schatz-Jakobsen, J.A., Larsen, C., Andersen, G.R.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.4010 Å
R-Value Free
0.238
R-Value Work
0.224
4P39 From PDB

Human C5a protein Secondary structure

C5a Protein Interaction

Recombinant C5a Protein Feature

C5a Protein, Mouse, Recombinant

51136-MNAE
High Purity
> 95 % as determined by SDS-PAGE.
Low Endotoxin
Please contact us for more information.
All Recombinant C5a protein

Recombinant C5a protein citations

Title
A Comparative Study of Impedance versus Optical Label-Free Systems Relative to Labelled Assays in a Predominantly Gi Coupled GPCR (C5aR) Signalling
Year
2012
Author
Halai, R;Croker, DE;Suen, JY;Fairlie, DP;Cooper, MA;
Journal
Biosensors
Title
Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a
Year
2013
Author
V Seow, J Lim, A Iyer, JY Suen, JK Ariffin…
Journal
The Journal of Immunology
Title
Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists
Year
2016
Author
Seow, V;Lim, J;Cotterell, AJ;Yau, MK;Xu, W;Lohman, RJ;Kok, WM;Stoermer, MJ;Sweet, MJ;Reid, RC;Suen, JY;Fairlie, DP;
Journal
Sci Rep
Title
Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1
Year
2019
Author
Pandey, S;Li, X;Srivastava, A;Baidya, M;Kumari, P;
Journal
bioRxiv
Title
Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming
Year
2019
Author
Hoogendijk, AJ;Pourfarzad, F;Aarts, CEM;Tool, ATJ;Hiemstra, IH;Grassi, L;Frontini, M;Meijer, AB;van den Biggelaar, M;Kuijpers, TW;
Journal
Cell Rep
Title
Interleukin-8 dysregulation is implicated in brain dysmaturation following preterm birth
Year
2020
Author
Sullivan, G;Galdi, P;Blesa Cabez, M;Borbye-Lorenzen, N;Stoye, DQ;Lamb, GJ;Evans, MJ;Quigley, AJ;Thrippleton, MJ;Skogstrand, K;Chandran, S;Bastin, ME;Boardman, JP;
Journal
Brain Behav. Immun.

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