c-Myc/MYC Protein Overview: Sequence, Structure, Function and Protein Interaction

c-Myc/MYC Protein Overview

The MYC protooncogene encodes a DNA-binding factor that can activate and repress transcription. Via this mechanism, MYC regulates expression of numerous target genes that control key cellular functions, including cell growth and cell cycle progression. MYC also has a critical role in DNA replication. Deregulated MYC expression resulting from various types of genetic alterations leads to constitutive MYC activity in a variety of cancers and promotes oncogenesis (Dominguez-Sola et al., 2007).

c-Myc/MYC protein name

Recommended name
Myc proto-oncogene protein
Short name
bHLHe39
Aliases
bHLHe39, c-Myc, MYCC
Alternative name
Class E basic helix-loop-helix protein 39 Proto-oncogene c-Myc Transcription factor p64

c-Myc/MYC Gene family protein

Basic helix-loop-helix proteins

c-Myc/MYC Protein Sequence

Species Human c-Myc/MYC protein
Length 439
Mass (Da) 48804
Sequence Human c-Myc/MYC protein sequence
Species Mouse c-Myc/MYC protein
Length 439
Mass (Da) 48971
Sequence Mouse c-Myc/MYC protein sequence
Species Rat c-Myc/MYC protein
Length 439
Mass (Da) 48898
Sequence Rat c-Myc/MYC protein sequence

c-Myc/MYC Protein Molecular Weight & PI

Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-439 Myc proto-oncogene protein.

Molecular weight (Da)

48804.08

Theoretical pI

5.33

c-Myc/MYC Protein Structure

CRYSTAL STRUCTURE OF YEAST KARYOPHERIN (IMPORTIN) ALPHA IN A COMPLEX WITH A C-MYC NLS PEPTIDE
Deposited
2000-01-30   Released:  2000-03-29
Deposition Author(s)
Conti, E.
Organism(s)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Homo sapiens
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.1000 Å
R-Value Free
0.277
R-Value Work
0.246
1EE4 From PDB

Human c-Myc/MYC protein Secondary structure

c-Myc/MYC Protein Interaction

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