c-Myc/MYC Gene Sequence, Family, Fuction and Expression Information

c-Myc/MYC cDNA / Gene Overview

MYC gene / cDNA is a protein-coding gene which located on 8q24.21. The MYC gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.215 organisms have orthologs with human gene MYC.

c-Myc/MYC cDNA / Gene Function

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

c-Myc/MYC cDNA / Gene Sequence

LOCUS
LOCUS NM_001354870 4515 bp mRNA linear PRI 11-AUG-2018
DEFINITION
Homo sapiens MYC proto-oncogene, bHLH transcription factor (MYC), transcript variant 2, mRNA.
ACCESSION
NM_001354870
VERSION
NM_001354870.1

This sequence information is just for reference only.

c-Myc/MYC Family & Reagents

c-Myc/MYC Gene family reagents (Basic helix-loop-helix proteins)

Approved Symbol Reagent list
HIF1A
MITF
Approved Symbol Reagent list
MAX
   

c-Myc/MYC cDNA / Gene Alias

  • bHLHe39
  • c-Myc
  • MYCC

c-Myc/MYC cDNA / Gene Expression

Ubiquitous expression in gall bladder (RPKM 49.6), esophagus (RPKM 44.6) and 25 other tissues

Recombinant c-Myc/MYC protein citations

Title
Expression of Insulin-Like Growth Factor Binding Protein-5 (IGFBP5) Reverses Cisplatin-Resistance in Esophageal Carcinoma
Year
2018
Author
Chan, D;Zhou, Y;Chui, CH;Lam, KH;Law, S;Chan, AS;Li, X;Lam, AK;Tang, JCO;
Journal
Cells
Title
Discovery of [1,2,3]triazolo[4,5-d]pyrimidine derivatives as highly potent, selective, and cellularly active USP28 inhibitors
Year
2019
Author
Liu, Z;Zhao, T;Li, Z;Sun, K;Fu, Y;Cheng, T;Guo, J;Yu, B;Shi, X;Liu, H;
Journal
Acta Pharmaceutica Sinica B