c-Myc/MYC Gene Sequence, Family, Fuction and Expression Information
c-Myc/MYC cDNA / Gene Overview
MYC gene / cDNA is a protein-coding gene which located on 8q24.21. The MYC gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.215 organisms have orthologs with human gene MYC.
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
c-Myc/MYC cDNA / Gene Sequence
LOCUS NM_001354870 4515 bp mRNA linear PRI 11-AUG-2018
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