c-Abl/ABL1 Protein Overview: Sequence, Structure, Function and Protein Interaction

c-Abl/ABL1 Protein Overview

c-Abl/ABL1 reagents

ABL1/NUP214 FUSION GENE, INCLUDED

c-Abl/ABL1 protein family

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.

c-Abl/ABL1 protein name

Recommended name
Tyrosine-protein kinase ABL1
Aliases
c-ABL, JTK7, p150
Alternative name
Abelson murine leukemia viral oncogene homolog 1 Abelson tyrosine-protein kinase 1 Proto-oncogene c-Abl p150

c-Abl/ABL1 Protein Sequence

Species Human c-Abl/ABL1 protein
Length 1130
Mass (Da) 122873
Sequence Human c-Abl/ABL1 protein sequence
Species Mouse c-Abl/ABL1 protein
Length 1123
Mass (Da) 122673
Sequence Mouse c-Abl/ABL1 protein sequence
Species
Length
Mass (Da)
Sequence

c-Abl/ABL1 Protein Molecular Weight & PI

Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 1-1130 Tyrosine-protein kinase ABL1.

Molecular weight (Da)

122872.56

Theoretical pI

8.84

c-Abl/ABL1 Protein Structure

Crystal structure of the ABL-SH3 domain complexed with the designed high-affinity peptide ligand P7 at pH 8
Deposited
2013-02-16   Released:  2014-01-29
Deposition Author(s)
Camara-Artigas, A.
Organism(s)
Homo sapiens
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
1.7000 Å
R-Value Free
0.209
R-Value Work
0.158
4J9H From PDB

Human c-Abl/ABL1 protein Secondary structure

c-Abl/ABL1 Protein Interaction

Recombinant c-Abl/ABL1 Protein Feature

c-Abl/ABL1 Protein, Human, Recombinant (GST Tag)

High Purity
> 75 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
The specific activity was determined to be 240 nmol/min/mg using synthetic Abl peptide (EAIYAAPFAKKK) as substrate.

Recombinant c-Abl/ABL1 protein citations

Title
A sensitive and microscale method for drug screening combining affinity probes and single molecule fluorescence correlation spectroscopy
Year
2015
Author
Ruan, L;Su, D;Shao, C;Wang, J;Dong, C;Huang, X;Ren, J;
Journal
Analyst
Title
Screening of break point cluster region Abelson tyrosine kinase inhibitors by capillary electrophoresis
Year
2018
Author
Xu, M;Zheng, M;Liu, G;Zhang, M;Kang, J;
Journal
J Chromatogr A
Title
Simple and Sensitive Method for Determination of Protein Kinase Activity Based on Surface Charge Change of Peptide-Modified Gold Nanoparticles As Substrates
Year
2018
Author
Yi, F;Huang, X;Ren, J;
Journal
Anal. Chem.
Title
Discovery of berberine that targetedly induce autophagic degradation of both BCR-ABL and BCR-ABL T315I through recruiting LRSAM1 for overcoming imatinib-resistance
Year
2020
Author
Yin, Z;Huang, G;Gu, C;Liu, Y;Yang, J;Fei, J;
Journal
Clin. Cancer Res.

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