BRG1 Gene Sequence, Family, Fuction and Expression Information

BRG1 cDNA / Gene Overview

SMARCA4 gene / cDNA is a protein-coding gene which located on 19p13.2. The SMARCA4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.185 organisms have orthologs with human gene SMARCA4.

BRG1 cDNA / Gene Function

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

BRG1 cDNA / Gene Sequence

LOCUS
LOCUS NM_003072 5703 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), transcript variant 3, mRNA.
ACCESSION
NM_003072
VERSION
NM_003072.3

This sequence information is just for reference only.

BRG1 cDNA / Gene Alias

  • ATP-dependent helicase SMARCA4
  • BAF190
  • brahma protein-like 1
  • BRG1
  • BRM / SWI2-related gene 1
  • FLJ39786
  • global transcription activator homologous sequence
  • homeotic gene regulator
  • hSNF2b
  • mitotic growth and transcription activator
  • nuclear protein GRB1
  • SNF2
  • SNF2-BETA
  • SNF2LB
  • SNF2-like 4
  • sucrose nonfermenting-like 4
  • SWI2

BRG1 cDNA / Gene Expression

Ubiquitous expression in testis (RPKM 21.8), brain (RPKM 14.5) and 25 other tissues