BRG1 Gene Sequence, Family, Fuction and Expression Information
BRG1 cDNA / Gene Overview
SMARCA4 gene / cDNA is a protein-coding gene which located on 19p13.2. The SMARCA4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.185 organisms have orthologs with human gene SMARCA4.
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
BRG1 cDNA / Gene Sequence
LOCUS NM_003072 5703 bp mRNA linear PRI 05-AUG-2018
Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), transcript variant 3, mRNA.
This sequence information is just for reference only.
BRG1 cDNA / Gene Alias
ATP-dependent helicase SMARCA4
brahma protein-like 1
BRM / SWI2-related gene 1
global transcription activator homologous sequence
homeotic gene regulator
mitotic growth and transcription activator
nuclear protein GRB1
sucrose nonfermenting-like 4
BRG1 cDNA / Gene Expression
Ubiquitous expression in testis (RPKM 21.8), brain (RPKM 14.5) and 25 other tissues
Successfully added to cart Please enter catalog numberSubmitted successfullyNetwork ErrorPlease enter your company namePlease enter your namePlease enter your emailPlease enter a valid email addressPlease enter some messageNot found.